| Tag | Content |
|---|
| CPLM ID | CPLM-007493 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | General vesicular transport factor p115 |
Protein Synonyms/Alias | Protein USO1 homolog; Transcytosis-associated protein; TAP; Vesicle-docking protein |
Gene Name | Uso1 |
Gene Synonyms/Alias | Vdp |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 202 | RSNGAIQKIVAFENA | acetylation | [1] | | 570 | KLKQLIEKRIGKENY | acetylation | [1] | | 618 | HEFTKLVKELEGVIT | acetylation | [1] | | 626 | ELEGVITKAIYKSSE | acetylation | [1] | | 791 | AEQVAELKQELSALK | acetylation | [1] | | 858 | SALLQETKELKNEIK | acetylation | [1] | | 861 | LQETKELKNEIKALS | acetylation | [1] | | 865 | KELKNEIKALSEERT | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. |
Sequence Annotation | REPEAT 20 60 ARM 1.
REPEAT 61 121 ARM 2.
REPEAT 123 163 ARM 3.
REPEAT 166 207 ARM 4.
REPEAT 208 253 ARM 5.
REPEAT 255 310 ARM 6.
REPEAT 311 354 ARM 7.
REPEAT 363 408 ARM 8.
REPEAT 420 459 ARM 9.
REPEAT 473 513 ARM 10.
REPEAT 518 571 ARM 11.
REPEAT 573 630 ARM 12.
REGION 1 637 Globular head.
MOD_RES 50 50 Phosphoserine (By similarity).
MOD_RES 202 202 N6-acetyllysine (By similarity).
MOD_RES 940 940 Phosphoserine. |
Keyword | Acetylation; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 959 AA |
Protein Sequence | MNFLRGVMGG QSAGPQHTEA ETIQKLCDRV ASSTLLDDRR NAVRALKSLS KKYRLEVGIQ 60
AMEHLIHVLQ TDRSDSEIIA YALDTLYNII SNDEEEEVEE NSTRQSEDLG SQFTEIFIKQ 120
PENVTLLLSL LEEFDFHVRW PGVRLLTSLL KQLGPPVQQI ILVSPMGVSK LMDLLADSRE 180
IIRNDGVLLL QALTRSNGAI QKIVAFENAF ERLLDIITEE GNSDGGIVVE DCLILLQNLL 240
KNNNSNQNFF KEGSYIQRMK AWFEVGDENP GWSAQKVTNL HLMLQLVRVL VSPTNPPGAT 300
SSCQKAMFQC GLLQQLCTIL MATGIPADIL TETINTVSEV IRGCQVNQDY FASVNAPSNP 360
PRPAIVVLLM SMVNERQPFV LRCAVLYCFQ CFLYKNEKGQ GEIVATLLPS TIDATGNSVS 420
AGQLLCGGLF STDSLSNWCA AVALAHALQG NATQKEQLLR VQLATSIGNP PVSLLQQCTN 480
ILSQGSKIQT RVGLLMLLCT WLSNCPIAVT HFLHNSANVP FLTGQIAENL GEEEQLVQGL 540
CALLLGISIY FNDNSLENYT KEKLKQLIEK RIGKENYIEK LGFISKHELY SRASQKPQPN 600
FPSPEYMIFD HEFTKLVKEL EGVITKAIYK SSEEDKKEEE VKKTLEQHDN IVTHYKNMIR 660
EQDLQLEELK QQVSTLKCQN EQLQTAVTQQ ASQIQQHKDQ YNLLKVQLGK DNHHQGSHSD 720
GAQVNGIQPE EISRLREEIE ELRSHQVLLQ SQLAEKDTVI ENLRSSQVSG MSEQALATCS 780
PRDAEQVAEL KQELSALKSQ LCSQSLEITR LQTENSELQQ RAETLAKSVP VEGESELVTA 840
AKTTDVEGRL SALLQETKEL KNEIKALSEE RTAIQKQLDS SNSTIAILQT EKDKLYLEVT 900
DSKKEQDDLL VLLADQDQKI LSLKSKLKDL GHPVEEEDES GDQEDDDDEL DDGDRDQDI 959 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara. GO:0008565; F:protein transporter activity; IEA:Compara. GO:0006944; P:cellular membrane fusion; IDA:RGD. GO:0006891; P:intra-Golgi vesicle-mediated transport; TAS:RGD. GO:0006886; P:intracellular protein transport; IEA:Compara. GO:0045056; P:transcytosis; IDA:RGD. GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |