UniProt Accession

 ARL5B_HUMAN; Q96KC2 

Genbank Protein ID

 AF494061; AK027275; BC024163 

Genbank Nucleotide ID

 AAM74076.1; BAB55011.1; AAH24163.1 

Protein Name

 ADP-ribosylation factor-like protein 5B 

Protein Synonyms/Alias

 ADP-ribosylation factor-like protein 8 

Gene Name

 ARL5B 

Gene Synonyms/Alias

 ARL8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	RERLAITKEELYRML	ubiquitination	[1, 2, 3, 4]
126	AVLIFANKQDMKGCM	ubiquitination	[4]
130	FANKQDMKGCMTAAE	ubiquitination	[3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Binds and exchanges GTP and GDP. 

Sequence Annotation

 NP_BIND 23 30 GTP.
 NP_BIND 66 70 GTP (By similarity).
 NP_BIND 125 128 GTP.
 BINDING 31 31 GTP.
 BINDING 159 159 GTP; via amide nitrogen.
 LIPID 2 2 N-myristoyl glycine (Potential).  

Keyword

 3D-structure; Complete proteome; GTP-binding; Lipoprotein; Myristate; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00328; SAR1GTPBP.