CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006271
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Long-chain-fatty-acid--CoA ligase 6 
Protein Synonyms/Alias
 Long-chain acyl-CoA synthetase 6; LACS 6; Long-chain-fatty-acid--CoA ligase, brain isozyme 
Gene Name
 Acsl6 
Gene Synonyms/Alias
 Acs2; Facl6 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
356RLLSDDMKALRPTIFacetylation[1]
376LLNRMYDKIFHQADTacetylation[1]
626GNYQELCKSKELKKAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. 
Sequence Annotation
  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Fatty acid metabolism; Ligase; Lipid metabolism; Magnesium; Membrane; Microsome; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Peroxisome; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 697 AA 
Protein Sequence
MQTQEILRIL RLPELSDLGQ FFRSLSATTL VSMGALAAIL AYWLTHRPKA LQPPCNLLMQ 60
SEEVEDSGGA RRSVIGDCTQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPEQPYQW 120
LSYQEVAKRA EFLGSGLLQH DCKVGTEQFI GVFAQNRPEW IIAELACYTY SMVVVPLYDT 180
LGPGSIRYII NTADICTVIV DKPHKAILLL EHVERKETPG LKLVILMEPF DDALRERGKK 240
CGVDIKSMQA IEDSGQENHR VPVPPRPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 300
LKVTESQWAP TCADVHFSYL PLAHMFERMV QSVVYCHGGR VGFFQGDIRL LSDDMKALRP 360
TIFPVVPRLL NRMYDKIFHQ ADTSLKRWLL EFAAKRKQAE VRSGIIRNNS IWDELFFNKI 420
QASLGGHVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV 480
GAPLPCNHIK LVDAEELNYW TSKGEGEICV KGPNVFKGYL KDEDRTKEAL DSDGWLHTGD 540
IGKWLPEGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS EPVAQIYVHG DSLKAFLVGI 600
VVPDPEVMPC WAQKKGIEGN YQELCKSKEL KKAILDDMVM LGKESGLHSF EQVKAIYIHC 660
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM 697 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
 GO:0015908; P:fatty acid transport; IGI:RGD.
 GO:0007405; P:neuroblast proliferation; IEA:Compara.
 GO:0048666; P:neuron development; IEP:RGD.
 GO:0008654; P:phospholipid biosynthetic process; IMP:RGD.
 GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
 GO:0010747; P:positive regulation of plasma membrane long-chain fatty acid transport; IMP:RGD.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IGI:RGD.
 GO:0009629; P:response to gravity; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0048545; P:response to steroid hormone stimulus; IEP:RGD.
 GO:0006641; P:triglyceride metabolic process; IGI:RGD. 
Interpro
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS