| Tag | Content |
|---|
| CPLM ID | CPLM-015129 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inositol-pentakisphosphate 2-kinase |
Protein Synonyms/Alias | Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase; InsP5 2-kinase |
Gene Name | Ippk |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 462 | KIVNYYSKTVHAKDD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. |
Sequence Annotation | MOTIF 136 140 EXKPK motif. |
Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 489 AA |
Protein Sequence | MEEGKMDENE WSYHGEGNKS LVVAHAQRCV VLRFLKFPPN KKKTSEEILQ HLQNIVDFGK 60
NVMKDFLGEN YVHCGEVVQL PLEFVKQLCL KIQCERPESR CDKDLDTFSG YAMCLPNLTR 120
LQTFHFAEHR PILCVEIKPK CGFIPFSNDV THEMKHKVCR YCMHQHLKVA TGKWKKISKY 180
CPLDLYSGNK QRMHFALRSL LQETQNNLRI FKNGELIYGC GDARSPVADL KELAHHLKPF 240
FFPSNGLASG PHCTKAVIRE LVHVITRVLL SSSEKARAGA LRLGLQGPRV CEASPFSRSL 300
HNQGKNTSEH SGLPKGCLLY KTLQVQMLDQ LDIEGLYPLY KRVEQYLEEF PEERKTLQID 360
GPYDEVFYQK LLDLSTEDDG TVAFALTKVQ QYRVAMTAKD CSIMIALSPC LQGTSSDQRP 420
VIPSSRSRLA FSVSVLDLDL KPYESIPHQY KLDSKIVNYY SKTVHAKDDT VRSTRFKEHE 480
DCTLVLHKV 489 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0035299; F:inositol pentakisphosphate 2-kinase activity; ISS:HGNC. GO:0052746; P:inositol phosphorylation; ISS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |