UniProt Accession

 GLO2_HUMAN; Q16775; A8K290; B4DRA7 

Genbank Protein ID

 AK290155; AK299173; AE006639; AC012180; BC000840; BC002627; X90999 

Genbank Nucleotide ID

 BAF82844.1; BAG61219.1; AAK61294.1; AAH00840.1; AAH02627.2; CAA62483.1 

Protein Name

 Hydroxyacylglutathione hydrolase, mitochondrial 

Protein Synonyms/Alias

 Glyoxalase II; Glx II 

Gene Name

 HAGH 

Gene Synonyms/Alias

 GLO2; HAGH1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
229	EYTINNLKFARHVEP	acetylation	[1]
249	REKLAWAKEKYSIGE	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. 

Sequence Annotation

 REGION 191 193 Substrate.
 REGION 221 223 Substrate.
 REGION 297 300 Substrate.
 METAL 102 102 Zinc 1.
 METAL 104 104 Zinc 1.
 METAL 106 106 Zinc 2.
 METAL 107 107 Zinc 2.
 METAL 158 158 Zinc 1.
 METAL 182 182 Zinc 1.
 METAL 182 182 Zinc 2.
 METAL 221 221 Zinc 2.
 MOD_RES 229 229 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Mitochondrion; Reference proteome; Transit peptide; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006750; P:glutathione biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 

Pfam

 PF00753; Lactamase_B 

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS