UniProt Accession

 NXN_HUMAN; Q6DKJ4; B4DXQ0; D3DTH2; Q3SWW6; Q6P3U6; Q7L4C6; Q9H9Q1 

Genbank Protein ID

 AK022676; AK027451; AK302073; AC015884; AC036164; AC087392; CH471108; CH471108; BC009327; BC063828; BC073845; BC104634 

Genbank Nucleotide ID

 BAB14171.1; BAB55122.1; BAG63462.1; EAW90640.1; EAW90641.1; AAH09327.2; AAH63828.1; AAH73845.1; AAI04635.1 

Protein Name

 Nucleoredoxin 

Protein Synonyms/Alias

  

Gene Name

 NXN 

Gene Synonyms/Alias

 NRX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
354	LIQPIAEKIIAKYKA	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). 

Sequence Annotation

 DOMAIN 167 321 Thioredoxin.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; NAD; Nucleus; Oxidoreductase; Reference proteome; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 435 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0047134; F:protein-disulfide reductase activity; IEA:EC.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IEA:Compara.
 GO:0072358; P:cardiovascular system development; ISS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS