UniProt Accession

 F5H246_HUMAN; F5H246 

Genbank Protein ID

 AL590730 

Genbank Nucleotide ID

  

Protein Name

 Protein NAMPTL 

Protein Synonyms/Alias

  

Gene Name

 NAMPTL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	DPVADPNKRSKKGRL	acetylation	[1]
52	DPVADPNKRSKKGRL	ubiquitination	[2]
76	FVTLEEGKGDLEEYG	ubiquitination	[3]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 120 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004516; F:nicotinate phosphoribosyltransferase activity; IEA:InterPro.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
 GO:0009435; P:NAD biosynthetic process; IEA:InterPro. 

Interpro

 IPR015977; Nic_PRibTrfase-like.
 IPR016471; Nicotinamide_PRibTrfase.
 IPR002638; Quinolinate_PRibosylTrfase_C. 

Pfam

 PF04095; NAPRTase 

SMART

  

PROSITE

  

PRINTS