UniProt Accession

 DPY30_HUMAN; Q9C005; D6W578 

Genbank Protein ID

 AF226998; CH471053; CH471053; BC015970 

Genbank Nucleotide ID

 AAK00640.1; EAX00463.1; EAX00466.1; AAH15970.1 

Protein Name

 Protein dpy-30 homolog 

Protein Synonyms/Alias

 Dpy-30-like protein; Dpy-30L 

Gene Name

 DPY30 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	ERIVENEKINAEKSS	acetylation	[1]
35	ERIVENEKINAEKSS	ubiquitination	[2, 3]
45	AEKSSKQKVDLQSLP	ubiquitination	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 35 35 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Chromatin regulator; Complete proteome; Golgi apparatus; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 99 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0048188; C:Set1C/COMPASS complex; IDA:UniProtKB.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0016197; P:endosomal transport; IMP:UniProtKB.
 GO:0051568; P:histone H3-K4 methylation; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007858; Dpy-30_motif. 

Pfam

 PF05186; Dpy-30 

SMART

  

PROSITE

  

PRINTS