CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020189
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 70, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 TMEM70 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88FLNTPSDKSEDGRLIubiquitination[1, 2]
201VFHQNDVKIPDAKHVubiquitination[1]
206DVKIPDAKHVFTTFYubiquitination[1, 3]
215VFTTFYAKTKSLLVNubiquitination[2]
217TTFYAKTKSLLVNPVubiquitination[1, 4, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Involved in biogenesis of mitochondrial ATP synthase. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 260 AA 
Protein Sequence
MLFLALGSPW AVELPLCGRR TALCAAAALR GPRASVSRAS SSSGPSGPVA GWSTGPSGAA 60
RLLRRPGRAQ IPVYWEGYVR FLNTPSDKSE DGRLIYTGNM ARAVFGVKCF SYSTSLIGLT 120
FLPYIFTQNN AISESVPLPI QIIFYGIMGS FTVITPVLLH FITKGYVIRL YHEATTDTYK 180
AITYNAMLAE TSTVFHQNDV KIPDAKHVFT TFYAKTKSLL VNPVLFPNRE DYIHLMGYDK 240
EEFILYMEET SEEKRHKDDK 260 
Gene Ontology
 GO:0032592; C:integral to mitochondrial membrane; IDA:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IMP:UniProtKB. 
Interpro
 IPR009724; DUF1301_TMEM70. 
Pfam
 PF06979; DUF1301 
SMART
  
PROSITE
  
PRINTS