UniProt Accession

 HNRLL_MOUSE; Q921F4; Q3UIK6; Q6IR44; Q8BIP6; Q91W02; Q99J40 

Genbank Protein ID

 AK034860; AK146879; BC004763; BC012849; BC071184 

Genbank Nucleotide ID

 BAC28858.1; BAE27500.1; AAH04763.1; AAH12849.2; AAH71184.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein L-like 

Protein Synonyms/Alias

  

Gene Name

 Hnrnpll 

Gene Synonyms/Alias

 Hnrpll 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
310	NDSWDYTKPYLGRRD	acetylation	[1]
483	YKDFAMSKNNRFTSA	ubiquitination	[2]
533	HEVLPFIKYKVFDAK	acetylation	[3]
544	FDAKASAKTLSGLLE	acetylation	[1, 4]
553	LSGLLEWKCKTDAVE	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. 

Sequence Annotation

 DOMAIN 125 199 RRM 1.
 DOMAIN 215 293 RRM 2.
 DOMAIN 384 458 RRM 3.
 MOD_RES 117 117 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 591 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0003729; F:mRNA binding; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:InterPro.
 GO:0033120; P:positive regulation of RNA splicing; ISS:UniProtKB. 

Interpro

 IPR006536; HnRNP-L_PTB.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

  

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS