UniProt Accession

 NUDT5_RAT; Q6AY63 

Genbank Protein ID

 BC079176 

Genbank Nucleotide ID

 AAH79176.1 

Protein Name

 ADP-sugar pyrophosphatase 

Protein Synonyms/Alias

 8-oxo-dGDP phosphatase; Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5 

Gene Name

 Nudt5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
42	TYMDPTGKTRTWETV	acetylation	[1]
57	KLTTRKGKSADAVSV	acetylation	[1]
210	ALKHANAKPFEVPFL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Hydrolyzes with similar activities ADP-ribose and ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). 

Sequence Annotation

 DOMAIN 57 197 Nudix hydrolase.
 REGION 46 47 Substrate binding; shared with dimeric
 MOTIF 97 118 Nudix box.
 METAL 96 96 Magnesium 1; via carbonyl oxygen (By
 METAL 112 112 Magnesium 2 (By similarity).
 METAL 112 112 Magnesium 3 (By similarity).
 METAL 116 116 Magnesium 1 (By similarity).
 METAL 116 116 Magnesium 3 (By similarity).
 METAL 166 166 Magnesium 3 (By similarity).
 BINDING 28 28 Substrate (By similarity).
 BINDING 84 84 Substrate (By similarity).
 BINDING 98 98 Substrate; via amide nitrogen (By
 BINDING 133 133 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 210 210 N6-acetyllysine (By similarity).
 MOD_RES 218 218 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0047631; F:ADP-ribose diphosphatase activity; IEA:EC.
 GO:0019144; F:ADP-sugar diphosphatase activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0030515; F:snoRNA binding; ISS:UniProtKB.
 GO:0009191; P:ribonucleoside diphosphate catabolic process; ISS:UniProtKB. 

Interpro

 IPR020476; Nudix_hydrolase.
 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS

 PR00502; NUDIXFAMILY.