UniProt Accession

 STK24_RAT; B0LT89; F1LML1 

Genbank Protein ID

 EU371958 

Genbank Nucleotide ID

 ABY76171.1 

Protein Name

 Serine/threonine-protein kinase 24 

Protein Synonyms/Alias

 Mammalian STE20-like protein kinase 3; MST-3; MST3b; STE20-like kinase MST3; Serine/threonine-protein kinase 24 35 kDa subunit; Mammalian STE20-like protein kinase 3 N-terminal; MST3/N; Serine/threonine-protein kinase 24 12 kDa subunit; Mammalian STE20-like protein kinase 3 C-terminal; MST3/C 

Gene Name

 Stk24 

Gene Synonyms/Alias

 Mst3; Stk3 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
130	TILREILKGLDYLHS	acetylation	[1]
272	AKELLKHKFIIRNAK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12 (By similarity). Acts as a key regulator of axon regeneration in the adult optic nerve and radial nerve. 

Sequence Annotation

 DOMAIN 24 274 Protein kinase.
 NP_BIND 30 38 ATP (By similarity).
 NP_BIND 100 102 ATP (By similarity).
 REGION 323 374 Nuclear export signal (NES) (By
 MOTIF 266 280 Bipartite nuclear localization signal (By
 ACT_SITE 144 144 Proton acceptor (By similarity).
 METAL 149 149 Magnesium (By similarity).
 METAL 162 162 Magnesium (By similarity).
 BINDING 53 53 ATP (By similarity).
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 178 178 Phosphothreonine; by autocatalysis (By
 MOD_RES 308 308 Phosphoserine (By similarity).
 MOD_RES 341 341 Phosphothreonine (By similarity).  

Keyword

 Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 431 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; ISS:UniProtKB.
 GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
 GO:0048680; P:positive regulation of axon regeneration; IMP:RGD.
 GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 

PRINTS