| Tag | Content |
|---|
| CPLM ID | CPLM-013171 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MARVEL domain-containing protein 2 |
Protein Synonyms/Alias | Tricellulin |
Gene Name | Marveld2 |
Gene Synonyms/Alias | Mrvldc2; Tric |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | TARTYSEKVEEYNLR | ubiquitination | [1] | | 388 | NDPSLSSKRKMCEAA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. |
Sequence Annotation | DOMAIN 185 364 MARVEL.
MOD_RES 117 117 Phosphoserine (By similarity).
MOD_RES 121 121 Phosphoserine (By similarity). |
Keyword | Cell junction; Cell membrane; Coiled coil; Complete proteome; Hearing; Membrane; Phosphoprotein; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 555 AA |
Protein Sequence | MSSSDARSRI RDRGYSEVPR DTSCPDGTIR TFQSLHSSEL AVSADPLPPP PLPLQPPFGP 60
SFYSSDTEEP AVAPDLKPVR RFVPDSWKNF FRGKKKDPEW DNPVSDIRYI SDGVECSPPA 120
SPARANHHPY KDPSRGSQGT FNSQHEADAM FAHDPYASLD RRTQTARTYS EKVEEYNLRY 180
AYMKSWAGLL RILGVVELLL GAGVFACVTA YIHKDNEWYN LFGYTQPYGM GGLGSLGNTY 240
GGYYYSGPKT PFVLVVAGLA WITTIIILVL GMSMYYRTIL LDSNWWPLTE FGVNVALFIL 300
YMAAAIVYVN DTNRGGLCYY PLFNTPMNAM FCRVEGGQIA AMIFLFVTMI VYLVSALVCL 360
KLWRHEAARR HREFLEQQEI NDPSLSSKRK MCEAAISDRQ RDQEVNVKDL RTTTKMTPEL 420
LSGHIPPGHI PKPIVMPDYV AKYPVIQTDD DRERYKAVFQ DQFSEYKELS AEVQAILRKF 480
DELDTVMSRL PHHSENRQEH ERISRIHEEF RKKKNDPSFL EKKERCDYLK NKLSHIKQRI 540
QEYDKVMNWD TQGYP 555 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0033010; C:paranodal junction; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0043220; C:Schmidt-Lanterman incisure; IDA:MGI. GO:0005923; C:tight junction; IDA:MGI. GO:0045216; P:cell-cell junction organization; IMP:MGI. GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |