UniProt Accession

 DPS1_HUMAN; Q5T2R2; Q53F75; Q6P473; Q86WQ8; Q9Y2W5 

Genbank Protein ID

 AF118395; AB210838; AK223414; AL390961; BC049211; BC063635 

Genbank Nucleotide ID

 AAD28559.1; BAE48216.1; BAD97134.1; CAI17280.1; AAH49211.1; AAH63635.1 

Protein Name

 Decaprenyl-diphosphate synthase subunit 1 

Protein Synonyms/Alias

 All-trans-decaprenyl-diphosphate synthase subunit 1; Decaprenyl pyrophosphate synthase subunit 1; Trans-prenyltransferase 1; TPT 1 

Gene Name

 PDSS1 

Gene Synonyms/Alias

 DPS1; TPRT 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	EKYTDPFKLGWRDLK	ubiquitination	[1, 2]
104	KLGWRDLKGLYEDIR	acetylation	[3]
104	KLGWRDLKGLYEDIR	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. 

Sequence Annotation

 METAL 180 180 Magnesium 1 (By similarity).
 METAL 180 180 Magnesium 2 (By similarity).
 METAL 184 184 Magnesium 1 (By similarity).
 METAL 184 184 Magnesium 2 (By similarity).
 METAL 307 307 Magnesium 3 (By similarity).
 BINDING 134 134 Isopentenyl diphosphate (By similarity).
 BINDING 137 137 Isopentenyl diphosphate (By similarity).
 BINDING 173 173 Isopentenyl diphosphate (By similarity).
 BINDING 189 189 Polyprenyl diphosphate (By similarity).
 BINDING 190 190 Isopentenyl diphosphate (By similarity).
 BINDING 266 266 Polyprenyl diphosphate (By similarity).
 BINDING 267 267 Polyprenyl diphosphate (By similarity).
 BINDING 304 304 Polyprenyl diphosphate (By similarity).
 BINDING 321 321 Polyprenyl diphosphate (By similarity).
 MOD_RES 57 57 Phosphotyrosine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Isoprene biosynthesis; Magnesium; Metal-binding; Mitochondrion; Phosphoprotein; Reference proteome; Transferase; Ubiquinone biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; IDA:HGNC.
 GO:0000010; F:trans-hexaprenyltranstransferase activity; IEA:Compara.
 GO:0050347; F:trans-octaprenyltranstransferase activity; IEA:Compara.
 GO:0008299; P:isoprenoid biosynthetic process; IDA:HGNC.
 GO:0051290; P:protein heterotetramerization; IEA:Compara.
 GO:0006744; P:ubiquinone biosynthetic process; IDA:HGNC. 

Interpro

 IPR000092; Polyprenyl_synt.
 IPR017446; Polyprenyl_synth-rel.
 IPR008949; Terpenoid_synth. 

Pfam

 PF00348; polyprenyl_synt 

SMART

  

PROSITE

 PS00723; POLYPRENYL_SYNTHASE_1
 PS00444; POLYPRENYL_SYNTHASE_2 

PRINTS