| Tag | Content |
|---|
| CPLM ID | CPLM-016813 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 |
Protein Synonyms/Alias | |
Gene Name | Ppwd1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 127 | EEGIEFVKHFRSHLG | acetylation | [1] | | 236 | IRLNPVYKAVVSSDK | acetylation | [1] | | 444 | TIVCTSFKKNRFYMF | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity). |
Sequence Annotation | REPEAT 88 126 WD 1.
REPEAT 131 170 WD 2.
REPEAT 221 260 WD 3.
REPEAT 278 319 WD 4.
DOMAIN 490 645 PPIase cyclophilin-type.
MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Complete proteome; Isomerase; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Rotamase; Spliceosome; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 646 AA |
Protein Sequence | MATESGSDSQ LRRRRRRDPE GSEKTELSER EPALAVAGSE ENDDENEERW VGPLPVEATL 60
AKKRKVLEFE RVYLDNLPSA SMYERSYMHR DVITHVVCTK TDFIITASHD GHVKFWKKIE 120
EGIEFVKHFR SHLGVIESIA VSSEGALFCS VGDDKAMKVF DVVNFDMINM LKLGYFPGQC 180
EWIYCPGDAI SSVAASEKST GKIFIYDGRG DNQPLHIFDK LHVSPLTQIR LNPVYKAVVS 240
SDKSGMIEYW TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK AYPTSICFSP DGKKIATIGS 300
DRKVRIFRFL TGKLMRVFDE SLSMFTELQQ MRQQLPDMEF GRRMAVEREL EKVDAVRLVN 360
IVFDETGHFV LYGTMLGIKV INVETNRCVR ILGKQENIRV MQLALFQGIA KKHRAAATIE 420
MKASENPVLQ NIQADPTIVC TSFKKNRFYM FTKREPEDTK TADSDRDVFN EKPSKEEVMA 480
ATQAEGPKRV SDSAIVHTSM GDIHIKLFPV ECPKTVENFC VHSRNGYYNG HTFHRIIKGF 540
MIQTGDPTGT GMGGESIWGG EFEDEFHSTL RHDRPYTLSM ANAGSNTNGS QFFITVVPTP 600
WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK TDKPYEDVSI INITVK 646 |
Gene Ontology | GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara. GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0006457; P:protein folding; IEA:UniProtKB-KW. GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |