CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microtubule-associated protein 1S 
Protein Synonyms/Alias
 MAP-1S; BPY2-interacting protein 1; Microtubule-associated protein 8; MAP1S heavy chain; MAP1S light chain 
Gene Name
 Map1s 
Gene Synonyms/Alias
 Bpy2ip1; Map8; Mtap1s 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
528GPGVVNTKPRVSQNGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis (By similarity). Involved in the formation of microtubule bundles. 
Sequence Annotation
 REGION 1 716 Necessary for the microtubule-organizing
 REGION 601 973 Necessary for interaction with RASSF1 (By
 REGION 645 880 Necessary for association with
 REGION 875 973 Necessary for association with actin.
 REGION 881 905 Necessary for the mitochondrial
 MOD_RES 462 462 Phosphoserine (By similarity).
 MOD_RES 593 593 Phosphoserine (By similarity).
 MOD_RES 684 684 Phosphoserine (By similarity).
 MOD_RES 724 724 Phosphoserine (By similarity).
 MOD_RES 831 831 Phosphoserine.  
Keyword
 Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; DNA-binding; Microtubule; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 973 AA 
Protein Sequence
MAAVMAAPEA VEAPSSLLLL VVGGECGCPG LLAYVMEELE RGVRSWEDVD PAVCSLDEQL 60
KAFVSRHSAT FSSIVKGQRS LHHRGETLET LVLLNPSDKS LCDELRNLLM DPAPHKLLVL 120
AGPCLEETGE LLLQTGGFSA HHFLQVLGDK EVQDALASAP AAPALTVSCP TFGDWALLGP 180
VPGLQLRLNP PAQLPASEGL RAFLEYVAES LEPPSPFELL EPPAAGGFLR LARPCCYVFP 240
GGLGDAAFFA VNGFTVLVNG GSNPKSSFWK LVRHLDRVDA VLVTHAGADS LPGLNSLLRR 300
KLAEREAAAG PQGQHEERLR RLLSPALGVV FLNAREAASR LRGGEDEAVC ARSLLRSLGI 360
APLPLQRGPQ PSCPTVLFEK LGVGRLELFV LHPPPGDPAA PACALLVWQP AAPGDKVVRV 420
LFPGRTPPAR LLDGLQRLQH LPCLRRPVVT THDLEAPSRA NSQDSLASRD SARKEPVRGT 480
VGSIANRSTV RREPALATRD QKKDTRSGPT QPTARDTRRS GPGVVNTKPR VSQNGPRAPV 540
LAAPLTAPVA ECPGEAENIL ESERPPAPSP TLSPAQSPPP TAPGNSPERL SLSPLRPEPA 600
PDASPSATTP TLTTPSLPAE LGSPHSTEVD ESLSVSFEQV LPAGDPGLSL PLRLARRSTS 660
PHDVDLCLVS PCEFSHRKPP PPASPGSSDS SARSQERPPE TPPTSVSESL PTLSDSDPVP 720
VADSDDDAGS ESAARDPPPT PRVPPPLPDV PGICMVDPEA LPPRARQPLN TTNPSRSRKA 780
PARPSSASAT PRAATVAAKT KGPAGDRNRP LSARSEPADR PGRVPLTRKP SVPKTVPKMA 840
SATRLSSGPS GRPAPLAAGS PVYLDLAYLP GGGAGHLDQN FFLRVRALCY VISGQGQRQE 900
EGLRAVLDAL LAGKRQWDLD LQVTLIPTFD SAVMHRWYEE THAQHQALGI RVLGSGSLVS 960
MQDEAFPACK VEF 973 
Gene Ontology
 GO:0005829; C:cytosol; ISS:HGNC.
 GO:0030425; C:dendrite; IDA:HGNC.
 GO:0005874; C:microtubule; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:HGNC.
 GO:0005634; C:nucleus; ISS:HGNC.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:HGNC.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0051015; F:actin filament binding; IDA:HGNC.
 GO:0048487; F:beta-tubulin binding; ISS:HGNC.
 GO:0003677; F:DNA binding; ISS:HGNC.
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0042802; F:identical protein binding; IDA:MGI.
 GO:0008017; F:microtubule binding; IDA:HGNC.
 GO:0007420; P:brain development; IEP:HGNC.
 GO:0097194; P:execution phase of apoptosis; ISS:BHF-UCL.
 GO:0001578; P:microtubule bundle formation; ISS:HGNC.
 GO:0048812; P:neuron projection morphogenesis; ISS:HGNC. 
Interpro
 IPR001279; Beta-lactamas-like.
 IPR026074; MAP1.
 IPR027322; MAP1S. 
Pfam
  
SMART
  
PROSITE
  
PRINTS