UniProt Accession

 6PGD_MOUSE; Q9DCD0; Q3UD80 

Genbank Protein ID

 AK002894; AK145602; AK150210; AK153409; AK155027; AK166733; AK166947; AK167215; AK168251 

Genbank Nucleotide ID

 BAB22439.1; BAE26535.1; BAE29381.1; BAE31969.1; BAE32999.1; BAE38978.1; BAE39134.1; BAE39341.1; BAE40201.1 

Protein Name

 6-phosphogluconate dehydrogenase, decarboxylating 

Protein Synonyms/Alias

  

Gene Name

 Pgd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
38	AFNRTVSKVDDFLAN	acetylation	[1, 2, 3]
38	AFNRTVSKVDDFLAN	ubiquitination	[4]
48	DFLANEAKGTKVVGA	ubiquitination	[4]
59	VVGAQSLKDMVSKLK	acetylation	[2]
59	VVGAQSLKDMVSKLK	ubiquitination	[4]
119	RCRDLKAKGILFVGS	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity). 

Sequence Annotation

 NP_BIND 10 15 NADP (By similarity).
 NP_BIND 33 35 NADP (By similarity).
 NP_BIND 75 77 NADP (By similarity).
 NP_BIND 478 481 NADP; shared with dimeric partner (By
 REGION 129 131 Substrate binding (By similarity).
 REGION 187 188 Substrate binding (By similarity).
 ACT_SITE 184 184 Proton acceptor (By similarity).
 ACT_SITE 191 191 Proton donor (By similarity).
 BINDING 103 103 NADP (By similarity).
 BINDING 103 103 Substrate (By similarity).
 BINDING 192 192 Substrate (By similarity).
 BINDING 261 261 Substrate; via amide nitrogen (By
 BINDING 288 288 Substrate (By similarity).
 BINDING 447 447 Substrate; shared with dimeric partner
 BINDING 453 453 Substrate; shared with dimeric partner
 MOD_RES 59 59 N6-acetyllysine (By similarity).
 MOD_RES 257 257 Phosphoserine (By similarity).
 MOD_RES 263 263 Phosphothreonine (By similarity).
 MOD_RES 267 267 Phosphothreonine (By similarity).
 MOD_RES 270 270 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Gluconate utilization; NADP; Oxidoreductase; Pentose shunt; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 483 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; ISS:UniProtKB.
 GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
 GO:0019322; P:pentose biosynthetic process; IDA:MGI.
 GO:0006098; P:pentose-phosphate shunt; ISS:UniProtKB.
 GO:0009051; P:pentose-phosphate shunt, oxidative branch; IEA:Compara. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR006114; 6PGDH_C.
 IPR006113; 6PGDH_decarbox.
 IPR006115; 6PGDH_NADP-bd.
 IPR006184; 6PGdom_BS.
 IPR013328; DH_multihelical.
 IPR012284; Fibritin/6PGD_C-extension.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00393; 6PGD
 PF03446; NAD_binding_2 

SMART

  

PROSITE

 PS00461; 6PGD 

PRINTS