| Tag | Content |
|---|
| CPLM ID | CPLM-016483 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Meiosis arrest female protein 1 |
Protein Synonyms/Alias | Limkain-b1 |
Gene Name | Marf1 |
Gene Synonyms/Alias | Kiaa0430; Lkap |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 89 | IRSLQQPKVQLSAIP | ubiquitination | [1] | | 795 | VDYRLSRKELQQLLQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Essential regulator of oogenesis required for female meiotic progression. Acts by down-regulating RNA transcripts, either at transcriptional of post-transcriptional level. |
Sequence Annotation | DOMAIN 352 489 NYN.
DOMAIN 781 860 RRM.
DOMAIN 865 939 HTH OST-type 1.
DOMAIN 993 1069 HTH OST-type 2.
DOMAIN 1089 1163 HTH OST-type 3.
DOMAIN 1165 1241 HTH OST-type 4.
DOMAIN 1249 1324 HTH OST-type 5.
DOMAIN 1325 1400 HTH OST-type 6.
DOMAIN 1401 1475 HTH OST-type 7.
DOMAIN 1476 1550 HTH OST-type 8.
MOD_RES 698 698 Phosphotyrosine.
MOD_RES 1081 1081 Phosphoserine (By similarity).
MOD_RES 1083 1083 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Differentiation; Meiosis; Oogenesis; Peroxisome; Phosphoprotein; Reference proteome; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1730 AA |
Protein Sequence | MEGKGTENPC SRTLGWFHQD NDAKPWLWKF SGCFSRPEQT LPLSSQTKEY MENKKAAVEL 60
KDIPSPLHVG SKFFPAVPLP DIRSLQQPKV QLSAIPKVSC CAHCPNEPST SPMRFGGGSG 120
SSGGSGSLIH TGSLLDSPST GTVTCQVGSG FAFQSVSSLQ NASTRNNLVG LSSDFPSMCV 180
ESNLPSCKHL SCCGKLHFQS CHSNVHKLHQ FQNLQGCASA GYFPCSDFPS GAPGHLEERL 240
SHSELTPHLC TNSLHLNVAP PVCLKGSLYC EDCLNKPARN SIIDAAKIWP NIPPPSTQPA 300
PPAIPVCNGC GTKGMEKETS LLLATSLGKT ASKFGSPEVA VTGQVLETLP PIGVFWDIEN 360
CSVPSGRSAT TVVQRIREKF FRGHREAEFI CVCDISKENK EVIQELNNCQ VTVAHINATA 420
KNAADDKLRQ SLRRFANTHT APATVVLVST DVNFALELSD LRHRHGFHII LVHKNQASEA 480
LLHHANQLIR FEEFISDLPP RLPLKIPQCH TLLYVYNLPA NKDGKSISNR LRRLSDNCGG 540
KVLSITGCSA ILRFINQDSA ERAQKRMENE DVFGNRIIVS FTPKHREFFE AKSSNAIADK 600
VKSPKKVKNT KLCLIKDTSE QSPSVKAMPG KVLQANSGSA TKTTNIKSLQ ELCRMESKSG 660
NRNSDHQQGH GRLAALPNSG PTASVPIVKN TGVTEPLYRS SQKKENPSSQ STVNSPVEKK 720
KREETVFQVS YPSAFSKLIA SRQVSPLLTS QSWSPRASPL AFNIANPSSG ADCPDPFANG 780
VDIQVSNVDY RLSRKELQQL LQEAFSKHGQ VKSVELSPHT DYQLKAIVQM RNLHEAICAV 840
NSLHRHKIGS KKILVSLSTG AANKSLSLLS TETMSILQDA PACCLPLFKF IDIYEKKYGH 900
KLNVSDLYKL TDTIAIREQG NGRLVCLLPS NQARQSPLGS SQSHDGSSSN CSPVLFEELE 960
YHEPVCKQHC SNKDFSELVF DPDSYKIPFV VLSLKVFAPQ VHSLLQTHQG TVPLLSFPDC 1020
YAAEFGDLEI TQDSHKGVPL EHFITCIPGV NIATAQNGVK VVKWIHNKPP PPNTDPWLLR 1080
SKSPVRNPQL IQFSREVIDL LKTQPSCILP VSNFIPSYHH HFGKQCRVSD YGYSKLIELL 1140
EAVPHVLQIL GMGSKRLMTL THRAQVKRFT QDLLKLLKSQ ASKQVIVRDF SQAYHWCFSK 1200
DWDVTEYGVC DLIDIISEIP DTTICLSQQD DDMVICIRKR ERTQDEIERT KQFSKDVVDL 1260
LRHQPHFRMP FNKFIPSYHH HFGRQCKLAY YGFTKLLELL EAIPEILQVL ECGEEKILTL 1320
TEVERFKALA AQFVKLLRSQ KGNCLMMTDL FTEYAKTFGY TFRLQDYDVS SVSALTQKLC 1380
HVVKVADMES GKQIQLINRK SLRSLTAQLL VLLMSWEGDA YLPVDELRRH YETTHSTPLN 1440
PCEYGFMTLT ELLKSLPYLV EVCTNDKAEE YVKLTSLYLF AKNVRSLLHT YHYQQIFLHE 1500
FSMAYNKYVG ETLQPKTYGY SSVEELLGAI PQVVWIKGHG HKRIVVLKND MKNRLSSFDL 1560
FSVNHEDQPA VSRQILAVPE SHLASELQLR TGTGPSQMEQ ELLHLASSSP VDLLCAPVPS 1620
CLPSPQLRPD PVILKPADLI QFEEHPQEPL GVLVLNQEEK SEVPLPVQKG NLSCDSSPSS 1680
PAASPAPPGP SSEAPRPLFS KDAVESPAKK QPKNRVKLAA NFSFAPVTKL 1730 |
Gene Ontology | GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0006302; P:double-strand break repair; IMP:MGI. GO:0007143; P:female meiosis; IMP:UniProtKB. GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB. GO:0048477; P:oogenesis; IMP:UniProtKB. GO:0010468; P:regulation of gene expression; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |