CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023277
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-azacytidine-induced protein 1 
Protein Synonyms/Alias
 Centrosomal protein of 131 kDa; Cep131; Pre-acrosome localization protein 1 
Gene Name
 AZI1 
Gene Synonyms/Alias
 CEP131; KIAA1118 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
57TGSEQKRKVLEATGPubiquitination[1]
122LSTAPSEKGATWNVLubiquitination[1]
157SPAGPRRKECTVALAubiquitination[1]
175TANNRSNKGAVGNCVubiquitination[1]
200SERAPPLKSSNQTAPubiquitination[1, 2]
214PSLNNIIKAATCEGSubiquitination[1]
228SESSGFGKLPKNVSSubiquitination[1, 3, 4]
254STGLPRRKEVTEEEAubiquitination[2]
320LLDLHQQKEAARRKAubiquitination[1, 2]
393GTAHQALKANNTGGGubiquitination[2]
507LTADNLEKFGKLSAFubiquitination[1, 2]
510DNLEKFGKLSAFPEPubiquitination[2, 3, 5]
656EAVVAELKQEDQRCTubiquitination[3]
678AQHELEIKKLKELMSubiquitination[2]
704SEKTKKIKEVTVRGLubiquitination[2]
717GLEPEIQKLIARHKQubiquitination[1]
955QERCSELKGQLGEAEubiquitination[2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 
Functional Description
 May play a role in spermatogenesis (By similarity). 
Sequence Annotation
 DOMAIN 269 289 IQ.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 78 78 Phosphoserine.
 MOD_RES 79 79 Phosphothreonine (By similarity).
 MOD_RES 89 89 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 150 150 Phosphoserine.
 MOD_RES 453 453 Phosphoserine.
 MOD_RES 798 798 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Phosphoprotein; Polymorphism; Reference proteome; Spermatogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1083 AA 
Protein Sequence
MKGTRAIGSV PERSPAGVDL SLTGLPPPVS RRPGSAATTK PIVRSVSVVT GSEQKRKVLE 60
ATGPGGSQAI NNLRRSNSTT QVSQPRSGSP RPTEPTDFLM LFEGSPSGKK RPASLSTAPS 120
EKGATWNVLD DQPRGFTLPS NARSSSALDS PAGPRRKECT VALAPNFTAN NRSNKGAVGN 180
CVTTMVHNRY TPSERAPPLK SSNQTAPSLN NIIKAATCEG SESSGFGKLP KNVSSATHSA 240
RNNTGGSTGL PRRKEVTEEE AERFIHQVNQ ATVTIQRWYR HQVQRRGAGA ARLEHLLQAK 300
REEQRQRSGE GTLLDLHQQK EAARRKAREE KARQARRAAI QELQQKRALR AQKASTAERG 360
PPENPRETRV PGMRQPAQEL SPTPGGTAHQ ALKANNTGGG LPAAGPGDRC LPTSDSSPEP 420
QQPPEDRTQD VLAQDAAGDN LEMMAPSRGS AKSRGPLEEL LHTLQLLEKE PDVLPRPRTH 480
HRGRYAWASE VTTEDDASSL TADNLEKFGK LSAFPEPPED GTLLSEAKLQ SIMSFLDEME 540
KSGQDQLDSQ QEGWVPEAGP GPLELGSEVS TSVMRLKLEV EEKKQAMLLL QRALAQQRDL 600
TARRVKETEK ALSRQLQRQR EHYEATIQRH LAFIDQLIED KKVLSEKCEA VVAELKQEDQ 660
RCTERVAQAQ AQHELEIKKL KELMSATEKA RREKWISEKT KKIKEVTVRG LEPEIQKLIA 720
RHKQEVRRLK SLHEAELLQS DERASQRCLR QAEELREQLE REKEALGQQE RERARQRFQQ 780
HLEQEQWALQ QQRQRLYSEV AEERERLGQQ AARQRAELEE LRQQLEESSS ALTRALRAEF 840
EKGREEQERR HQMELNTLKQ QLELERQAWE AGRTRKEEAW LLNREQELRE EIRKGRDKEI 900
ELVIHRLEAD MALAKEESEK AAESRIKRLR DKYEAELSEL EQSERKLQER CSELKGQLGE 960
AEGENLRLQG LVRQKERALE DAQAVNEQLS SERSNLAQVI RQEFEDRLAA SEEETRQAKA 1020
ELATLQARQQ LELEEVHRRV KTALARKEEA VSSLRTQHEA AVKRADHLEE LLEQHRRPTP 1080
STK 1083 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
 PS50096; IQ 
PRINTS