CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bifunctional polynucleotide phosphatase/kinase 
Protein Synonyms/Alias
 Polynucleotide kinase 3'-phosphatase, isoform CRA_b 
Gene Name
 Pnkp 
Gene Synonyms/Alias
 mCG_23134 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
150SLGWESLKKLLVFTAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 522 AA 
Protein Sequence
MSQLGSRGRL WLQSPTGGPP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRNQ VELIADPESR 60
TVAVKQLGVN PSTVGVQELK PGLSGSLSLG DVLYLVNGLY PLTLRWEELS TSGSQPDAPP 120
DTPGDPEEGE DTEPQKKRVR KSSLGWESLK KLLVFTASGV KPQGKVAAFD LDGTLITTRS 180
GKVFPTSPSD WRILYPEIPK KLQELAAEGY KLVIFTNQMG IGRGKLPAEV FKGKVEAVLE 240
KLGVPFQVLV ATHAGLNRKP VSGMWDHLQE QANEGIPISV EDSVFVGDAA GRLANWAPGR 300
KKKDFSCADR LFALNVGLPF ATPEEFFLKW PAARFELPAF DPRTISSAGP LYLPESSSLL 360
SPNPEVVVAV GFPGAGKSTF IQEHLVSAGY VHVNRDTLGS WQRCVSSCQA ALRQGKRVVI 420
DNTNPDVPSR ARYIQCAKDA GVPCRCFNFC ATIEQARHNN RFREMTDPSH APVSDMVMFS 480
YRKQFEPPTL AEGFLEILEI PFRLQEHLDP ALQRLYRQFS EG 522 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:Compara.
 GO:0019201; F:nucleotide kinase activity; IEA:Compara.
 GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:Compara.
 GO:0042769; P:DNA damage response, detection of DNA damage; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 
Interpro
 IPR000253; FHA_dom.
 IPR023214; HAD-like_dom.
 IPR006549; HAD-SF_hydro_IIIA.
 IPR027417; P-loop_NTPase.
 IPR013954; PNK3P.
 IPR015636; PNK_3Pase_euk.
 IPR006550; PNK_3Pase_met.
 IPR006551; Polynucleotide_phosphatase.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF08645; PNK3P 
SMART
  
PROSITE
  
PRINTS