UniProt Accession

 SC11A_HUMAN; P67812; B2RAD7; O75957; P21378; Q53FQ8 

Genbank Protein ID

 AF108945; AF061737; AK223224; AK314146; CH471101; BC000359; BC014508; AF090315 

Genbank Nucleotide ID

 AAD19640.1; AAD17526.1; BAD96944.1; BAG36834.1; EAX01954.1; AAH00359.3; AAH14508.1; AAC36354.1 

Protein Name

 Signal peptidase complex catalytic subunit SEC11A 

Protein Synonyms/Alias

 Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SPase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18 

Gene Name

 SEC11A 

Gene Synonyms/Alias

 SEC11L1; SPC18; SPCS4A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	PIVHRVLKIHEKQNG	ubiquitination	[1]
104	RVLKIHEKQNGHIKF	ubiquitination	[1]
110	EKQNGHIKFLTKGDN	ubiquitination	[1]
114	GHIKFLTKGDNNAVD	ubiquitination	[1, 2]
127	VDDRGLYKQGQHWLE	ubiquitination	[1, 2]
135	QGQHWLEKKDVVGRA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). 

Sequence Annotation

 ACT_SITE 56 56 By similarity.  

Keyword

 Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Microsome; Protease; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0006465; P:signal peptide processing; IEA:InterPro.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006412; P:translation; TAS:Reactome. 

Interpro

 IPR019758; Pept_S26A_signal_pept_1_CS.
 IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
 IPR019759; Peptidase_S24_S26.
 IPR015927; Peptidase_S24_S26A/B/C.
 IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
 IPR001733; Peptidase_S26B. 

Pfam

 PF00717; Peptidase_S24 

SMART

  

PROSITE

 PS00501; SPASE_I_1
 PS00761; SPASE_I_3 

PRINTS

 PR00728; SIGNALPTASE.