CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039261
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein unc-13 homolog A 
Protein Synonyms/Alias
  
Gene Name
 Unc13a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
764VVKIPDAKGDDAWKVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1638 AA 
Protein Sequence
LHLCLFTVKK AKFDGAQEKF NTYVTLKVQN VKSTTIAVRG SQPSWEQDFM FEINRLDLGL 60
TVEVWNKGLI WDTMVGTVWI PLRTIRQSNE EGPGEWLTLD SQAIMADSEI CGTKDPTFHR 120
ILLDAHFELP LDIPEEEARY WAKKLEQLNA MRDQDEYSFQ DQQDKPLPVP SSQCCNWNYF 180
GWGEQNDDPD SAVDDRDSDY RSETSNSIPP PYYTTSQPNA SVHQYSVRPP PLGSRESYSD 240
SMHSYEEFSE PRALRWLWDW GVAGNARAHL TEHFYLGGTC FMMCVRESDN NLLAFHRCGS 300
QALNSVVWAE LEREAGIPQS RSKPLPAFPG SREAEEGQEG QDAMSRAKAN WLRAFNKVRM 360
QLQEVSDTAS PRPLLSMATS VLQARGEGEM SKSLWFKGGP GGGLIIIDSM PDIRKRKPIP 420
LVSDLAMSLV QSRKAGITSA LASSTLNNEE LKNHVYKKTL QALIYPISCT TPHNFEVWTA 480
TTPTYCYECE GLLWGIARQG MRCTECGVKC HEKCQDLLNA DCLQRAAEKS SKHGAEDRTQ 540
NIIMVLKDRM KIRERNKPEI FELIQEVFAV TKSAHTQQMK AVKQSVLDGT SKWSAKISIT 600
VVCAQGLQAK DKTGSSDPYV TVQVGKTKKR TKTIYGNLNP VWEENFHFEC HNSSDRIKVR 660
VWDEDDDIKS RVKQRFKRES DDFLGQTIIE VRTLSGEMDV WYNLDKRTDK SAVSGAIRLH 720
ISVEIKGEEK VAPYHVQYTC LHENLFHFVT DVQNNGVVKI PDAKGDDAWK VYYDETAQEI 780
VDEFAMRYGV ESIYQAMTHF ACLSSKYMCP GVPAVMSTLL ANINAYYAHT TASTNVSASD 840
RFAASNFGKE RFVKLLDQLH NSLRIDLSMY RNNFPASSPE RLQDLKSTVD LLTSITFFRM 900
KVQELQSPPR ASQVVKDCVK ACLNSTYEYI FNNCHELYGR EYQTDPAKKG EVPPEEQGPS 960
IKNLDFWSKL ITLIVSIIEE DKNSYTPCLN QELGRGRARG RKCVLSSRSQ SDPKALPIHA 1020
CMRTCVCVCV CVHTEAKAFF MAPTAERDSL NSSKQFIVTA ENECVKPYPI ENEEVSRDFL 1080
HGALERDKKD GFQQTSEHAL FSCSVVDVFS QLNQSFEIIK KLECPDPQIV GHYMRRFAKT 1140
ISNVLLQYAD IVSKDFASYC SKEKEKVPCI LMNNTQQLRV QLEKMFEAMG GKELDAEASG 1200
TLKELQVKLN NVLDELSHVF ATSFQPHIEE CVRQMGDILS QVKGTGNVPA SACSSVAQDA 1260
DNVLQPIMDL LDSNLTLFAK ICEKTVLKRV LKELWKLVMN TMERTIVLPP LTDQTVRGTL 1320
LRKHGKGLEK GRVKLPSHSD GTQMIFNAAK ELGQLSKLKD HMVREEAKSL TPKQCAVVEL 1380
ALDTIKQYFH AGGVGLKKTF LEKSPDLQSL RYALSLYTQA TDLLIKTFVQ TQSAQVHGGK 1440
GTRFTLSEDV CPEMGSGVED PVGEVSVHVE LFTHPGTGEQ KVTVKVVAAN DLKWQTSGIF 1500
RPFIEVNIVG PQLSDKKRKF ATKSKNNSWA PKYNESFQFS LSADAGPECY ELQVCVKDYC 1560
FAREDRTVGL AVLQLRELAQ RGSAACWLPL GRRIHMDDTG LTVLRILSQR SNDEVAKEFV 1620
KLKSDTRSAE EGGAAPAP 1638 
Gene Ontology
 GO:0019992; F:diacylglycerol binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035249; P:synaptic transmission, glutamatergic; IEA:InterPro.
 GO:0016188; P:synaptic vesicle maturation; IEA:InterPro.
 GO:0016082; P:synaptic vesicle priming; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR010439; Ca-dep_secretion_activator.
 IPR014770; Munc13_1.
 IPR014772; Munc13_dom-2.
 IPR019558; Munc13_subgr_dom-2.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR027080; Unc-13.
 IPR027082; Unc13A. 
Pfam
 PF00130; C1_1
 PF00168; C2
 PF06292; DUF1041
 PF10540; Membr_traf_MHD 
SMART
 SM00109; C1
 SM00239; C2 
PROSITE
 PS50004; C2
 PS51258; MHD1
 PS51259; MHD2
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00360; C2DOMAIN.