UniProt Accession

 G3V3Z8_HUMAN; G3V3Z8 

Genbank Protein ID

 AC004846; AC005280; AL391733 

Genbank Nucleotide ID

  

Protein Name

 Protein numb homolog 

Protein Synonyms/Alias

  

Gene Name

 NUMB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
142	GFPALSQKMSPFKRQ	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 507 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0034332; P:adherens junction organization; IEA:Compara.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0021670; P:lateral ventricle development; IEA:Compara.
 GO:0060487; P:lung epithelial cell differentiation; IEA:Compara.
 GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Compara.
 GO:0021849; P:neuroblast division in subventricular zone; IEA:Compara.
 GO:0050769; P:positive regulation of neurogenesis; IEA:Compara.
 GO:0030862; P:positive regulation of polarized epithelial cell differentiation; IEA:Compara. 

Interpro

 IPR010449; Numb_domain. 

Pfam

 PF06311; NumbF 

SMART

  

PROSITE

  

PRINTS