UniProt Accession

 CHTOP_MOUSE; Q9CY57; Q0VBG3; Q3U7V6; Q3UF43; Q3V105; Q5XJG9; Q8C5N4; Q9D7T3; Q9DB03; Q9DC54; Q9JJ95 

Genbank Protein ID

 AB041654; AK004558; AK005377; AK008885; AK010866; AK047914; AK077960; AK132769; AK149010; AK152492; CH466547; BC083333; BC120651 

Genbank Nucleotide ID

 BAA95102.1; BAB23371.1; BAB23984.2; BAB25951.1; BAB27232.2; BAC33189.1; BAC37084.1; BAE21348.1; BAE28718.1; BAE31263.1; EDL15130.1; AAH83333.1; AAI20652.1 

Protein Name

 Chromatin target of PRMT1 protein 

Protein Synonyms/Alias

 Friend of PRMT1 protein; Small arginine- and glycine-rich protein; SRAG 

Gene Name

 Chtop 

Gene Synonyms/Alias

 Fop; MNCb-1706 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
70	PSVQAALKLKQKSLK	ubiquitination	[1]
82	SLKQRLGKSNIQARL	ubiquitination	[1]
214	LTRPVLTKEQLDNQL	ubiquitination	[1]
227	QLDAYMSKTKGHLDA	ubiquitination	[1]
229	DAYMSKTKGHLDAEL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. 

Sequence Annotation

 REGION 154 207 Interaction with PRMT1.
 MOD_RES 243 243 Phosphothreonine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Methylation; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 249 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR025715; FoP_duplication. 

Pfam

 PF13865; FoP_duplication 

SMART

  

PROSITE

  

PRINTS