| Tag | Content |
|---|
| CPLM ID | CPLM-018715 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ceramide synthase 2 |
Protein Synonyms/Alias | CerS2; LAG1 longevity assurance homolog 2; Translocating chain-associating membrane protein homolog 3; TRAM homolog 3 |
Gene Name | Cers2 |
Gene Synonyms/Alias | Lass2; Trh3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 93 | HFYQTSGKQPKQVEV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (By similarity). |
Sequence Annotation | DOMAIN 131 332 TLC.
DNA_BIND 67 128 Homeobox.
MOD_RES 341 341 Phosphoserine.
MOD_RES 346 346 Phosphothreonine.
MOD_RES 348 348 Phosphoserine.
MOD_RES 349 349 Phosphoserine.
CARBOHYD 19 19 N-linked (GlcNAc...). |
Keyword | Complete proteome; DNA-binding; Endoplasmic reticulum; Glycoprotein; Homeobox; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 380 AA |
Protein Sequence | MLQTLYDYFW WERLWLPVNL TWADLEDKDG RVYAKASDLY ITLPLALLFL VIRYFFELYV 60
ATPLAALLNV KEKTRLRAPP NATLEHFYQT SGKQPKQVEV DLLSRQSGLS GRQVERWFRR 120
RRNQDRPSLL KKFREASWRF TYYLIAFVAG MAVTVDKPWF YDLRKVWEGY PIQSIIPSQY 180
WYYMIELSFY WSLLFSIASD VKRKDFKEQI IHHVATIILL CFSWFANYVR AGTLIMALHD 240
ASDYLLESAK MFNYAGWKNT CNNLFIVFAI VFIITRLVIM PFWILHCTMI YPLELYPAFF 300
GYYFFNFMMA VLQMLHIFWA YFILRMAHKF ITGKLIEDER SDREETESSE GEETAAGAGA 360
KSRLLANGHP ILNNNHPKND 380 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0050291; F:sphingosine N-acyltransferase activity; IDA:MGI. GO:0046513; P:ceramide biosynthetic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |