CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003851
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aspartokinase 
Protein Synonyms/Alias
 Aspartate kinase 
Gene Name
 HOM3 
Gene Synonyms/Alias
 YER052C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
61SARSSYTKAEGTTSRubiquitination[1]
109LNPALQAKLVDDTNKacetylation[2]
116KLVDDTNKELELVKKacetylation[2]
435LGSVDITKKLSIVSLacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
  
Sequence Annotation
 DOMAIN 367 440 ACT 1.
 DOMAIN 442 527 ACT 2.
 MOD_RES 333 333 Phosphothreonine.  
Keyword
 Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Threonine biosynthesis; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 527 AA 
Protein Sequence
MPMDFQPTSS HSNWVVQKFG GTSVGKFPVQ IVDDIVKHYS KPDGPNNNVA VVCSARSSYT 60
KAEGTTSRLL KCCDLASQES EFQDIIEVIR QDHIDNADRF ILNPALQAKL VDDTNKELEL 120
VKKYLNASKV LGEVSSRTVD LVMSCGEKLS CLFMTALCND RGCKAKYVDL SHIVPSDFSA 180
SALDNSFYTF LVQALKEKLA PFVSAKERIV PVFTGFFGLV PTGLLNGVGR GYTDLCAALI 240
AVAVNADELQ VWKEVDGIFT ADPRKVPEAR LLDSVTPEEA SELTYYGSEV IHPFTMEQVI 300
RAKIPIRIKN VQNPLGNGTI IYPDNVAKKG ESTPPHPPEN LSSSFYEKRK RGATAITTKN 360
DIFVINIHSN KKTLSHGFLA QIFTILDKYK LVVDLISTSE VHVSMALPIP DADSLKSLRQ 420
AEEKLRILGS VDITKKLSIV SLVGKHMKQY IGIAGTMFTT LAEEGINIEM ISQGANEINI 480
SCVINESDSI KALQCIHAKL LSERTNTSNQ FEHAIDERLE QLKRLGI 527 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004072; F:aspartate kinase activity; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0009090; P:homoserine biosynthetic process; IMP:SGD.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
 GO:0009086; P:methionine biosynthetic process; IMP:SGD.
 GO:0009088; P:threonine biosynthetic process; IDA:SGD. 
Interpro
 IPR001048; Asp/Glu/Uridylate_kinase.
 IPR001341; Asp_kinase_dom.
 IPR018042; Aspartate_kinase_CS. 
Pfam
 PF00696; AA_kinase 
SMART
  
PROSITE
 PS51671; ACT
 PS00324; ASPARTOKINASE 
PRINTS