UniProt Accession

 F8WIR1_MOUSE; F8WIR1 

Genbank Protein ID

 AC034099 

Genbank Nucleotide ID

  

Protein Name

 Cathepsin D 

Protein Synonyms/Alias

  

Gene Name

 Ctsd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
54	ILKGPITKYSMQSSP	acetylation	[1]
62	YSMQSSPKTTEPVSE	ubiquitination	[2]
127	HHKYNSDKSSTYVKN	acetylation	[1, 3]
127	HHKYNSDKSSTYVKN	succinylation	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Aspartyl protease; Complete proteome; Disulfide bond; Hydrolase; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005764; C:lysosome; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004190; F:aspartic-type endopeptidase activity; IDA:MGI.
 GO:0000045; P:autophagic vacuole assembly; IMP:MGI.
 GO:0006508; P:proteolysis; IC:MGI. 

Interpro

 IPR001461; Peptidase_A1.
 IPR021109; Peptidase_aspartic.
 IPR001969; Peptidase_aspartic_AS.
 IPR012848; Propep_A1. 

Pfam

 PF07966; A1_Propeptide
 PF00026; Asp 

SMART

  

PROSITE

 PS00141; ASP_PROTEASE 

PRINTS

 PR00792; PEPSIN.