UniProt Accession

 INS_BOVIN; P01317 

Genbank Protein ID

 M54979 

Genbank Nucleotide ID

 AAA30722.1 

Protein Name

 Insulin 

Protein Synonyms/Alias

 Insulin B chain; Insulin A chain 

Gene Name

 INS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
53	RGFFYTPKARREVEG	glycation	[1, 2]

Reference

 [1] Mass spectrometry characterization of the glycation sites of bovine insulin by tandem mass spectrometry.
 Guedes S, Vitorino R, Domingues MR, Amado F, Domingues P.
 J Am Soc Mass Spectrom. 2009 Jul;20(7):1319-26. [PMID: 19369093]
 [2] Oxidative modifications in glycated insulin.
 Guedes S, Vitorino R, Domingues MR, Amado F, Domingues P.
 Anal Bioanal Chem. 2010 Jul;397(5):1985-95. [PMID: 20496032] 

Functional Description

 Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. 

Sequence Annotation

 DISULFID 31 91 Interchain (between B and A chains).
 DISULFID 43 104 Interchain (between B and A chains).
 DISULFID 90 95  

Keyword

 3D-structure; Carbohydrate metabolism; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glucose metabolism; Hormone; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 105 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR004825; Insulin.
 IPR016179; Insulin-like.
 IPR022353; Insulin_CS.
 IPR022352; Insulin_family. 

Pfam

 PF00049; Insulin 

SMART

 SM00078; IlGF 

PROSITE

 PS00262; INSULIN 

PRINTS

 PR00277; INSULIN.
 PR00276; INSULINFAMLY.