CPLM-009707

Genbank Nucleotide ID

Dynein light chain Tctex-type 1

Protein Synonyms/Alias

Protein CW-1; T-complex testis-specific protein 1 homolog

TCTEL1; TCTEX-1; TCTEX1

Homo sapiens (Human)

Position	Peptide	Type	References
38	GNAYQHSKVNQWTTN	ubiquitination	[1, 2, 3]
56	QTLSQLTKLGKPFKY	ubiquitination	[3, 4, 5, 6]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein.

REGION 41 113 Interaction with GNB1 (By similarity).
MOD_RES 1 1 N-acetylmethionine.

Acetylation; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoplasmic inwards viral transport; Cytoskeleton; Dynein; Golgi apparatus; Host-virus interaction; Microtubular inwards viral transport; Microtubule; Mitosis; Motor protein; Neurogenesis; Phosphoprotein; Reference proteome; Transport; Virus entry into host cell.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0003774; F:motor activity; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0000132; P:establishment of mitotic spindle orientation; ISS:UniProtKB.
GO:0019060; P:intracellular transport of viral proteins in host cell; IMP:UniProtKB.
GO:0075521; P:microtubule-dependent intracellular transport of viral material to nucleus; IEA:UniProtKB-KW.
GO:0007067; P:mitosis; IEA:UniProtKB-KW.
GO:0050768; P:negative regulation of neurogenesis; ISS:UniProtKB.
GO:0048812; P:neuron projection morphogenesis; IEA:Compara.
GO:0051493; P:regulation of cytoskeleton organization; IEA:Compara.
GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.
GO:0032314; P:regulation of Rac GTPase activity; IEA:Compara.
GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.