UniProt Accession

 RAB5B_HUMAN; P61020; A8K982; B4DKD7; P35239; P35277; Q6PIK9; Q86TH0; Q8IXL2 

Genbank Protein ID

 X54871; AF498937; AK292597; AK296517; BX537408; AC034102; CH471054; CH471054; BC032740; BC040143; BC050558; BC056422; BC065298 

Genbank Nucleotide ID

 CAA38653.1; AAM21085.1; BAF85286.1; BAG59149.1; CAD97650.1; EAW96862.1; EAW96864.1; AAH32740.1; AAH40143.1; AAH50558.2; AAH56422.2; AAH65298.2 

Protein Name

 Ras-related protein Rab-5B 

Protein Synonyms/Alias

  

Gene Name

 RAB5B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	ARAKTWVKELQRQAS	ubiquitination	[1]
134	VIALAGNKADLANKR	ubiquitination	[2, 3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Protein transport. Probably involved in vesicular traffic (By similarity). 

Sequence Annotation

 NP_BIND 27 35 GTP.
 NP_BIND 75 79 GTP (By similarity).
 NP_BIND 133 136 GTP.
 NP_BIND 163 165 GTP.
 MOTIF 49 57 Effector region (Potential).
 MOD_RES 2 2 N-acetylthreonine.
 LIPID 212 212 S-geranylgeranyl cysteine (By
 LIPID 213 213 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Endosome; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0007032; P:endosome organization; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0030100; P:regulation of endocytosis; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.