UniProt Accession

 TXNL1_MOUSE; Q8CDN6; O70379; Q3TI92 

Genbank Protein ID

 AF052660; AK029807; AK150326; AK167954; AK168712; BC061123 

Genbank Nucleotide ID

 AAC40183.1; BAC26626.1; BAE29469.1; BAE39954.1; BAE40554.1; AAH61123.1 

Protein Name

 Thioredoxin-like protein 1 

Protein Synonyms/Alias

 32 kDa thioredoxin-related protein 

Gene Name

 Txnl1 

Gene Synonyms/Alias

 Trp32; Txnl 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MVGVKPVGSDPD	ubiquitination	[1]
28	GSRLAVVKFTMRGCG	ubiquitination	[1]
85	TFLFFRNKVRIDQYQ	ubiquitination	[1]
102	DAVGLEEKIKQHLEN	ubiquitination	[1]
104	VGLEEKIKQHLENDP	acetylation	[2]
104	VGLEEKIKQHLENDP	ubiquitination	[1]
121	NEDADIPKGYMDLMP	ubiquitination	[1]
181	PVKLYSMKFQGPDNG	ubiquitination	[1]
192	PDNGQGPKYVKIFIN	acetylation	[2]
192	PDNGQGPKYVKIFIN	ubiquitination	[1]
226	ELTEDDIKEDGIVPL	ubiquitination	[1]
279	ATNMNDFKRVVGKKG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Active thioredoxin with a redox potential of about -250 mV (By similarity). 

Sequence Annotation

 DOMAIN 2 109 Thioredoxin.
 DOMAIN 115 285 PITH.
 MOD_RES 113 113 Phosphoserine.
 DISULFID 34 37 Redox-active (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Disulfide bond; Electron transport; Nucleus; Phosphoprotein; Proteasome; Redox-active center; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro. 

Interpro

 IPR008979; Galactose-bd-like.
 IPR010400; PITH_dom.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF06201; PITH
 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS51532; PITH
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS