CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007054
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Manganese transporter SMF1 
Protein Synonyms/Alias
  
Gene Name
 SMF1 
Gene Synonyms/Alias
 ESP1; YOL122C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
33EVFELRDKKDSTVVIubiquitination[1]
34VFELRDKKDSTVVIEubiquitination[1, 2]
297RLLDYDVKHGNYTVSubiquitination[2]
309TVSEEQDKVKKSKSTubiquitination[2]
314QDKVKKSKSTEEIMEubiquitination[2]
323TEEIMEEKYFNYRPTubiquitination[2]
532GMEIENGKDVKIVYMubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 High-affinity manganese transporter involved in manganese uptake from the extracellular environment. Contributes also to cellular accumulation of other divalent metal ions such as cadmium, cobalt, copper, iron and nickel. 
Sequence Annotation
 MOD_RES 24 24 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; Manganese; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 575 AA 
Protein Sequence
MVNVGPSHAA VAVDASEARK RNISEEVFEL RDKKDSTVVI EGEAPVRTFT SSSSNHERED 60
TYVSKRQVMR DIFAKYLKFI GPGLMVSVAY IDPGNYSTAV DAGASNQFSL LCIILLSNFI 120
AIFLQCLCIK LGSVTGLDLS RACREYLPRW LNWTLYFFAE CAVIATDIAE VIGTAIALNI 180
LIKVPLPAGV AITVVDVFLI MFTYKPGASS IRFIRIFECF VAVLVVGVCI CFAIELAYIP 240
KSTSVKQVFR GFVPSAQMFD HNGIYTAISI LGATVMPHSL FLGSALVQPR LLDYDVKHGN 300
YTVSEEQDKV KKSKSTEEIM EEKYFNYRPT NAAIKYCMKY SMVELSITLF TLALFVNCAI 360
LVVAGSTLYN SPEADGADLF TIHELLSRNL APAAGTIFML ALLLSGQSAG VVCTMSGQIV 420
SEGHINWKLQ PWQRRLATRC ISIIPCLVIS ICIGREALSK ALNASQVVLS IVLPFLVAPL 480
IFFTCKKSIM KTEITVDHTE EDSHNHQNNN DRSAGSVIEQ DGSSGMEIEN GKDVKIVYMA 540
NNWIITVIAI IVWLFLSLLN VYAIVQLGMS HGDIS 575 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0022890; F:inorganic cation transmembrane transporter activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015295; F:solute:hydrogen symporter activity; IDA:SGD.
 GO:0015691; P:cadmium ion transport; IGI:SGD.
 GO:0006876; P:cellular cadmium ion homeostasis; IGI:SGD.
 GO:0006878; P:cellular copper ion homeostasis; IGI:SGD.
 GO:0030026; P:cellular manganese ion homeostasis; IMP:SGD.
 GO:0006825; P:copper ion transport; IGI:SGD.
 GO:0006826; P:iron ion transport; IGI:SGD.
 GO:0006828; P:manganese ion transport; IMP:SGD. 
Interpro
 IPR001046; NRAMP-like. 
Pfam
 PF01566; Nramp 
SMART
  
PROSITE
  
PRINTS
 PR00447; NATRESASSCMP.