UniProt Accession

 D3Z7B6_MOUSE; D3Z7B6 

Genbank Protein ID

 AC114539; AC156982 

Genbank Nucleotide ID

  

Protein Name

 Suppressor of fused homolog 

Protein Synonyms/Alias

  

Gene Name

 Sufu 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
303	QPRRLSGKDTEQIRE	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 467 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0072372; C:primary cilium; IDA:MGI.
 GO:0008013; F:beta-catenin binding; IDA:MGI.
 GO:0008134; F:transcription factor binding; ISO:MGI.
 GO:0042994; P:cytoplasmic sequestering of transcription factor; IGI:MGI.
 GO:0001947; P:heart looping; IMP:MGI.
 GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IGI:MGI.
 GO:1901621; P:negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IMP:MGI.
 GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IMP:MGI. 

Interpro

 IPR007768; SUFU-like.
 IPR024314; SUFU_C.
 IPR020941; SUFU_domain. 

Pfam

 PF05076; SUFU
 PF12470; SUFU_C 

SMART

  

PROSITE

  

PRINTS