UniProt Accession

 ELOV1_HUMAN; Q9BW60; B4DP24; Q53HT2; Q5JUY3; Q8WXU3; Q9NVD9; Q9Y396 

Genbank Protein ID

 AF336793; AF151846; AK001653; AK222498; AK298163; AL139289; BC000618 

Genbank Nucleotide ID

 AAL71993.1; AAD34083.1; BAA91813.1; BAD96218.1; BAG60436.1; CAB92758.1; AAH00618.1 

Protein Name

 Elongation of very long chain fatty acids protein 1 

Protein Synonyms/Alias

 3-keto acyl-CoA synthase ELOVL1; ELOVL fatty acid elongase 1; ELOVL FA elongase 1; Very-long-chain 3-oxoacyl-CoA synthase 1 

Gene Name

 ELOVL1 

Gene Synonyms/Alias

 SSC1; CGI-88 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	PRIMANRKPFQLRGF	ubiquitination	[1, 2]
275	NGAPGIAKVKAN***	ubiquitination	[3]
277	APGIAKVKAN*****	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. 

Sequence Annotation

 MOTIF 275 279 Di-lysine motif (Potential).  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; NAS:UniProtKB.
 GO:0009922; F:fatty acid elongase activity; IDA:UniProtKB.
 GO:0034625; P:fatty acid elongation, monounsaturated fatty acid; IDA:UniProtKB.
 GO:0019367; P:fatty acid elongation, saturated fatty acid; IDA:UniProtKB.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:0030148; P:sphingolipid biosynthetic process; IMP:UniProtKB.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome.
 GO:0042761; P:very long-chain fatty acid biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR002076; GNS1_SUR4. 

Pfam

 PF01151; ELO 

SMART

  

PROSITE

 PS01188; ELO 

PRINTS