| Tag | Content |
|---|
| CPLM ID | CPLM-008085 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Folylpolyglutamate synthase, mitochondrial |
Protein Synonyms/Alias | Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase |
Gene Name | Fpgs |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 37 | SGSAYEAKTASFQDA | ubiquitination | [1] | | 62 | ASYLEQVKRQRSDPQ | ubiquitination | [1] | | 244 | WQKGGIFKPGVPAFT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10-methylenetetrahydrofolate, 10- formyltetrahydrofolate and 5-formyltetrahydrofolate are the best substrates. Folic acid and 5-methyltetrahydrofolate can also act as substrates. |
Sequence Annotation | NP_BIND 103 109 ATP (Potential).
MOD_RES 33 33 Phosphoserine. |
Keyword | Alternative initiation; Alternative promoter usage; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Ligase; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; One-carbon metabolism; Phosphoprotein; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 587 AA |
Protein Sequence | MMKSTRSLPM SWPVREKFWW EAAMEWKDPS GSAYEAKTAS FQDAVRTLNT LQTNASYLEQ 60
VKRQRSDPQA QLEAMEMYLA RSGLQVEDLN RLNIIHVTGT KGKGSTCAFT ERILRNYGLK 120
TGFFSSPHMV QVRERIRING KPISPELFTK HFWCLYNQLE EFKDDSHVSM PSYFRFLTLM 180
AFHVFLQEKV DLAVVEVGIG GAFDCTNIIR KPVVCGVSSL GIDHTSLLGD TVEKIAWQKG 240
GIFKPGVPAF TVVQPEGPLA VLRDRAQQIG CPLYLCPPLE ALEEVGLPLS LGLEGAHQRS 300
NAALALQLAH CWLERQDHQD IQELKVSRPS IRWQLPLAPV FRPTPHMRRG LRDTVWPGRT 360
QILQRGPLTW YLDGAHTTSS VQACVHWYRQ SLERSKRTDG GSEVHILLFN STGDRDSAAL 420
LKLLQPCQFD YAVFCPNVTE VSSIGNADQQ NFTVTLDQVL LRCLQHQQHW NGLAEKQASS 480
NLWSSCGPDP AGPGSLLLAP HPPQPTRTSS LVFSCISHAL LWISQGRDPI FQPQSLPRNL 540
LNHPTANSGA SILREAAAIH VLVTGSLHLV GGVLKLLDPS MSQ 583 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IEA:EC. GO:0007420; P:brain development; IEA:Compara. GO:0001889; P:liver development; IEA:Compara. GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. GO:0031100; P:organ regeneration; IEA:Compara. GO:0042221; P:response to chemical stimulus; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |