| Tag | Content |
|---|
| CPLM ID | CPLM-022928 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | AF4/FMR2 family member 4 |
Protein Synonyms/Alias | ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein |
Gene Name | AFF4 |
Gene Synonyms/Alias | AF5Q31; MCEF; HSPC092 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 881 | SSKEVKVKCWGPGAF | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. |
Sequence Annotation | MOD_RES 387 387 Phosphoserine.
MOD_RES 388 388 Phosphoserine.
MOD_RES 389 389 Phosphoserine.
MOD_RES 392 392 Phosphoserine.
MOD_RES 549 549 Phosphoserine.
MOD_RES 671 671 Phosphoserine.
MOD_RES 674 674 Phosphothreonine.
MOD_RES 694 694 Phosphoserine.
MOD_RES 703 703 Phosphoserine.
MOD_RES 706 706 Phosphoserine.
MOD_RES 712 712 Phosphotyrosine.
MOD_RES 814 814 Phosphoserine.
MOD_RES 836 836 Phosphoserine.
MOD_RES 1043 1043 Phosphoserine.
MOD_RES 1055 1055 Phosphoserine.
MOD_RES 1058 1058 Phosphoserine.
MOD_RES 1062 1062 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1163 AA |
Protein Sequence | MNREDRNVLR MKERERRNQE IQQGEDAFPP SSPLFAEPYK VTSKEDKLSS RIQSMLGNYD 60
EMKDFIGDRS IPKLVAIPKP TVPPSADEKS NPNFFEQRHG GSHQSSKWTP VGPAPSTSQS 120
QKRSSGLQSG HSSQRTSAGS SSGTNSSGQR HDRESYNNSG SSSRKKGQHG SEHSKSRSSS 180
PGKPQAVSSL NSSHSRSHGN DHHSKEHQRS KSPRDPDANW DSPSRVPFSS GQHSTQSFPP 240
SLMSKSNSML QKPTAYVRPM DGQESMEPKL SSEHYSSQSH GNSMTELKPS SKAHLTKLKI 300
PSQPLDASAS GDVSCVDEIL KEMTHSWPPP LTAIHTPCKT EPSKFPFPTK ESQQSNFGTG 360
EQKRYNPSKT SNGHQSKSML KDDLKLSSSE DSDGEQDCDK TMPRSTPGSN SEPSHHNSEG 420
ADNSRDDSSS HSGSESSSGS DSESESSSSD SEANEPSQSA SPEPEPPPTN KWQLDNWLNK 480
VNPHKVSPAS SVDSNIPSSQ GYKKEGREQG TGNSYTDTSG PKETSSATPG RDSKTIQKGS 540
ESGRGRQKSP AQSDSTTQRR TVGKKQPKKA EKAAAEEPRG GLKIESETPV DLASSMPSSR 600
HKAATKGSRK PNIKKESKSS PRPTAEKKKY KSTSKSSQKS REIIETDTSS SDSDESESLP 660
PSSQTPKYPE SNRTPVKPSS VEEEDSFFRQ RMFSPMEEKE LLSPLSEPDD RYPLIVKIDL 720
NLLTRIPGKP YKETEPPKGE KKNVPEKHTR EAQKQASEKV SNKGKRKHKN EDDNRASESK 780
KPKTEDKNSA GHKPSSNRES SKQSAAKEKD LLPSPAGPVP SKDPKTEHGS RKRTISQSSS 840
LKSSSNSNKE TSGSSKNSSS TSKQKKTEGK TSSSSKEVKV KCWGPGAFEN HSTCHVTFPG 900 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:HPA. GO:0005730; C:nucleolus; IDA:HPA. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0007286; P:spermatid development; IEA:Compara. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |