CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TNF receptor-associated factor 5 
Protein Synonyms/Alias
 RING finger protein 84 
Gene Name
 TRAF5 
Gene Synonyms/Alias
 RNF84 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MAYSEEHKGMPCGFIubiquitination[1]
85VPICPVDKEVIKSQEubiquitination[1]
89PVDKEVIKSQEVFKDubiquitination[1]
95IKSQEVFKDNCCKREubiquitination[1]
100VFKDNCCKREVLNLYubiquitination[1]
154PVLRKDLKEHLSASCubiquitination[1]
234YGCAVTDKRRNLQQHubiquitination[1]
256HMRLVLEKNVQLEEQubiquitination[1]
293KKLEKEFKQFAQLFGubiquitination[1]
353MEAVDTVKQKITLLEubiquitination[1]
355AVDTVKQKITLLENNubiquitination[1]
375VLEEETNKHDTHINIubiquitination[1]
405EGTCYNGKLIWKVTDubiquitination[1]
493LLDQSGKKNIMETFKubiquitination[1]
500KNIMETFKPDPNSSSubiquitination[1]
534HSVLENAKNAYIKDDubiquitination[1]
539NAKNAYIKDDTLFLKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. 
Sequence Annotation
 DOMAIN 403 549 MATH.
 ZN_FING 45 85 RING-type.
 ZN_FING 127 181 TRAF-type 1.
 ZN_FING 182 239 TRAF-type 2.
 REGION 345 557 Interaction with EIF2AK2/PKR.  
Keyword
 Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC 60
GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV 120
ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL 180
QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ 240
HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG 300
KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE 360
NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA 420
VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ 480
RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD 540
DTLFLKVAVD LTDLEDL 557 
Gene Ontology
 GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR002083; MATH.
 IPR013323; SIAH-type.
 IPR012227; TNF_rcpt--assoc_TRAF.
 IPR008974; TRAF-like.
 IPR027130; TRAF5.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS.
 IPR001293; Znf_TRAF. 
Pfam
 PF00917; MATH
 PF00097; zf-C3HC4 
SMART
 SM00061; MATH
 SM00184; RING 
PROSITE
 PS50144; MATH
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2
 PS50145; ZF_TRAF 
PRINTS