UniProt Accession

 SHOC2_HUMAN; Q9UQ13; A8K9W8; B3KR23; O76063; Q5VZS8; Q5VZS9 

Genbank Protein ID

 AF068920; AF054828; AB020669; AK090820; AK292833; AL158163; AL158163; CH471066; BC050445 

Genbank Nucleotide ID

 AAC39856.1; AAC25698.1; BAA74885.2; BAG52235.1; BAF85522.1; CAH72812.1; CAH72813.1; EAW49548.1; AAH50445.1 

Protein Name

 Leucine-rich repeat protein SHOC-2 

Protein Synonyms/Alias

 Protein soc-2 homolog; Protein sur-8 homolog 

Gene Name

 SHOC2 

Gene Synonyms/Alias

 KIAA0862 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
369	MEHNRINKIPFGIFS	ubiquitination	[1, 2]
383	SRAKVLSKLNMKDNQ	ubiquitination	[2, 3]
475	AYLKDLQKLVLTNNQ	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. 

Sequence Annotation

 REPEAT 101 122 LRR 1.
 REPEAT 124 145 LRR 2.
 REPEAT 147 169 LRR 3.
 REPEAT 170 191 LRR 4.
 REPEAT 193 214 LRR 5.
 REPEAT 216 237 LRR 6.
 REPEAT 239 260 LRR 7.
 REPEAT 262 283 LRR 8.
 REPEAT 285 307 LRR 9.
 REPEAT 308 329 LRR 10.
 REPEAT 332 353 LRR 11.
 REPEAT 356 377 LRR 12.
 REPEAT 380 400 LRR 13.
 REPEAT 403 424 LRR 14.
 REPEAT 426 448 LRR 15.
 REPEAT 449 470 LRR 16.
 REPEAT 472 494 LRR 17.
 REPEAT 495 516 LRR 18.
 REPEAT 518 540 LRR 19.
 REPEAT 542 563 LRR 20.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Leucine-rich repeat; Nucleus; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 582 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0000164; C:protein phosphatase type 1 complex; IDA:UniProtKB.
 GO:0019903; F:protein phosphatase binding; IDA:UniProtKB.
 GO:0019888; F:protein phosphatase regulator activity; TAS:UniProtKB.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; NAS:UniProtKB.
 GO:0046579; P:positive regulation of Ras protein signal transduction; IMP:UniProtKB.
 GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR027036; SHOC2. 

Pfam

 PF00560; LRR_1
 PF12799; LRR_4 

SMART

 SM00369; LRR_TYP 

PROSITE

 PS51450; LRR 

PRINTS