UniProt Accession

 RNF11_MOUSE; Q9QYK7; B1AU36; B1AU37; Q9EQI1 

Genbank Protein ID

 AB024427; AF220206; AL669905; AL669905; CH466527; CH466527; CH466527; BC010299; BC028255 

Genbank Nucleotide ID

 BAA84682.1; AAG44245.1; CAM13662.1; CAM13663.1; EDL30703.1; EDL30704.1; EDL30705.1; AAH10299.1; AAH28255.1 

Protein Name

 RING finger protein 11 

Protein Synonyms/Alias

 NEDD4 WW domain-binding protein 2; Sid 1669 

Gene Name

 Rnf11 

Gene Synonyms/Alias

 N4wbp2; Sid1669 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
82	GLIQHLPKGVYDPGR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. 

Sequence Annotation

 ZN_FING 99 140 RING-type.
 MOTIF 37 40 WW-binding.
 MOD_RES 135 135 Phosphothreonine; by PKB/AKT1 (By
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Endosome; Lipoprotein; Metal-binding; Myristate; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
 GO:0000151; C:ubiquitin ligase complex; IPI:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IPI:MGI. 

Interpro

 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF13639; zf-RING_2 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS