UniProt Accession

 K2C80_HUMAN; Q6KB66; Q6P1A5; Q7Z3Q0 

Genbank Protein ID

 AJ717743; BX537567; CH471111; BC065180 

Genbank Nucleotide ID

 CAG30732.1; CAD97784.1; EAW58237.1; AAH65180.1 

Protein Name

 Keratin, type II cytoskeletal 80 

Protein Synonyms/Alias

 Cytokeratin-80; CK-80; Keratin-80; K80; Type-II keratin Kb20 

Gene Name

 KRT80 

Gene Synonyms/Alias

 KB20 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
71	LLVPLDVKLDPAVQQ	ubiquitination	[1, 2]
93	EMKALNDKFASLIGK	ubiquitination	[1, 2, 3]
100	KFASLIGKVQALEQR	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

  

Sequence Annotation

 REGION 1 82 Head.
 REGION 82 118 Coil 1A.
 REGION 83 390 Rod.
 REGION 119 135 Linker 1.
 REGION 136 227 Coil 1B.
 REGION 228 251 Linker 12.
 REGION 252 390 Coil 2.
 REGION 391 452 Tail.
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 396 396 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Intermediate filament; Keratin; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 452 AA 

Protein Sequence

Gene Ontology

 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR003054; Keratin_II. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS

 PR01276; TYPE2KERATIN.