CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pericentrin 
Protein Synonyms/Alias
 Kendrin; Pericentrin-B 
Gene Name
 PCNT 
Gene Synonyms/Alias
 KIAA0402; PCNT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2860KDNVSLTKALSTVTQubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. 
Sequence Annotation
 REGION 2983 3246 Interaction with NEK2.
 REGION 3195 3208 Calmodulin-binding.
 MOD_RES 191 191 Phosphothreonine.
 MOD_RES 366 366 Phosphoserine (By similarity).
 MOD_RES 682 682 Phosphoserine.
 MOD_RES 1712 1712 Phosphoserine (By similarity).
 MOD_RES 2044 2044 Phosphoserine.
 MOD_RES 2177 2177 Phosphoserine.
 MOD_RES 2327 2327 Phosphoserine.
 MOD_RES 2477 2477 Phosphoserine.
 MOD_RES 2486 2486 Phosphoserine.
 MOD_RES 3302 3302 Phosphoserine.  
Keyword
 Alternative splicing; Calmodulin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dwarfism; Microtubule; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3336 AA 
Protein Sequence
MFTVSDHPPE QHGMFTVGDH PPEQRGMFTV SDHPPEQHGM FTVSDHPPEQ RGMFTISDHQ 60
PEQRGMFTVS DHTPEQRGIF TISDHPAEQR GMFTKECEQE CELAITDLES GREDEAGLHQ 120
SQAVHGLELE ALRLSLSNMH TAQLELTQAN LQKEKETALT ELREMLNSRR AQELALLQSR 180
QQHELELLRE QHAREKEEVV LRCGQEAAEL KEKLQSEMEK NAQIVKTLKE DWESEKDLCL 240
ENLRKELSAK HQSEMEDLQN QFQKELAEQR AELEKIFQDK NQAERALRNL ESHHQAAIEK 300
LREDLQSEHG RCLEDLEFKF KESEKEKQLE LENLQASYED LKAQSQEEIR RLWSQLDSAR 360
TSRQELSELH EQLLARTSRV EDLEQLKQRE KTQHESELEQ LRIYFEKKLR DAEKTYQEDL 420
TLLQQRLQGA REDALLDSVE VGLSCVGLEE KPEKGRKDHV DELEPERHKE SLPRFQAELE 480
ESHRHQLEAL ESPLCIQHEG HVSDRCCVET SALGHEWRLE PSEGHSQELP WVHLQGVQDG 540
DLEADTERAA RVLGLETEHK VQLSLLQTEL KEEIELLKIE NRNLYGKLQH ETRLKDDLEK 600
VKHNLIEDHQ KELNNAKQKT ELMKQEFQRK ETDWKVMKEE LQREAEEKLT LMLLELREKA 660
ESEKQTIINK FELREAEMRQ LQDQQAAQIL DLERSLTEQQ GRLQQLEQDL TSDDALHCSQ 720
CGREPPTAQD GELAALHVKE DCALQLMLAR SRFLEERKEI TEKFSAEQDA FLQEAQEQHA 780
RELQLLQERH QQQLLSVTAE LEARHQAALG ELTASLESKQ GALLAARVAE LQTKHAADLG 840
ALETRHLSSL DSLESCYLSE FQTIREEHRQ ALELLRADFE EQLWKKDSLH QTILTQELEK 900
LKRKHEGELQ SVRDHLRTEV STELAGTVAH ELQGVHQGEF GSEKKTALHE KEETLRLQSA 960
QAQPFHQEEK ESLSLQLQKK NHQVQQLKDQ VLSLSHEIEE CRSELEVLQQ RRERENREGA 1020
NLLSMLKADV NLSHSERGAL QDALRRLLGL FGETLRAAVT LRSRIGERVG LCLDDAGAGL 1080
ALSTAPALEE TWSDVALPEL DRTLSECAEM SSVAEISSHM RESFLMSPES VRECEQPIRR 1140
VFQSLSLAVD GLMEMALDSS RQLEEARQIH SRFEKEFSFK NEETAQVVRK HQELLECLKE 1200
ESAAKAELAL ELHKTQGTLE GFKVETADLK EVLAGKEDSE HRLVLELESL RRQLQQAAQE 1260
QAALREECTR LWSRGEATAT DAEAREAALR KEVEDLTKEQ SETRKQAEKD RSALLSQMKI 1320
LESELEEQLS QHRGCAKQAE AVTALEQQVA SLDKHLRNQR QFMDEQAAER EHEREEFQQE 1380
IQRLEGQLRQ AAKPQPWGPR DSQQAPLDGE VELLQQKLRE KLDEFNELAI QKESADRQVL 1440
MQEEEIKRLE EMNINIRKKV AQLQEEVEKQ KNIVKGLEQD KEVLKKQQMS SLLLASTLQS 1500
TLDAGRCPEP PSGSPPEGPE IQLEVTQRAL LRRESEVLDL KEQLEKMKGD LESKNEEILH 1560
LNLKLDMQNS QTAVSLRELE EENTSLKVIY TRSSEIEELK ATIENLQENQ KRLQKEKAEE 1620
IEQLHEVIEK LQHELSLMGP VVHEVSDSQA GSLQSELLCS QAGGPRGQAL QGELEAALEA 1680
KEALSRLLAD QERRHSQALE ALQQRLQGAE EAAELQLAEL ERNVALREAE VEDMASRIQE 1740
FEAALKAKEA TIAERNLEID ALNQRKAAHS AELEAVLLAL ARIRRALEQQ PLAAGAAPPE 1800
LQWLRAQCAR LSRQLQVLHQ RFLRCQVELD RRQARRATAH TRVPGAHPQP RMDGGAKAQV 1860
TGDVEASHDA ALEPVVPDPQ GDLQPVLVTL KDAPLCKQEG VMSVLTVCQR QLQSELLLVK 1920
NEMRLSLEDG GKGKEKVLED CQLPKVDLVA QVKQLQEKLN RLLYSMTFQN VDAADTKSLW 1980
PMASAHLLES SWSDDSCDGE EPDISPHIDT CDANTATGGV TDVIKNQAID ACDANTTPGG 2040
VTDVIKNWDS LIPDEMPDSP IQEKSECQDM SLSSPTSVLG GSRHQSHTAE AGPRKSPVGM 2100
LDLSSWSSPE VLRKDWTLEP WPSLPVTPHS GALSLCSADT SLGDRADTSL PQTQGPGLLC 2160
SPGVSAAALA LQWAESPPAD DHHVQRTAVE KDVEDFITTS FDSQETLSSP PPGLEGKADR 2220
SEKSDGSGFG ARLSPGSGGP EAQTAGPVTP ASISGRFQPL PEAMKEKEVR PKHVKALLQM 2280
VRDESHQILA LSEGLAPPSG EPHPPRKEDE IQDISLHGGK TQEVPTACPD WRGDLLQVVQ 2340
EAFEKEQEMQ GVELQPRLSG SDLGGHSSLL ERLEKIIREQ GDLQEKSLEH LRLPDRSSLL 2400
SEIQALRAQL RMTHLQNQEK LQHLRTALTS AEARGSQQEH QLRRQVELLA YKVEQEKCIA 2460
GDLQKTLSEE QEKANSVQKL LAAEQTVVRD LKSDLCESRQ KSEQLSRSLC EVQQEVLQLR 2520
SMLSSKENEL KAALQELESE QGKGRALQSQ LEEEQLRHLQ RESQSAKALE ELRASLETQR 2580
AQSSRLCVAL KHEQTAKDNL QKELRIEHSR CEALLAQERS QLSELQKDLA AEKSRTLELS 2640
EALRHERLLT EQLSQRTQEA CVHQDTQAHH ALLQKLKEEK SRVVDLQAML EKVQQQALHS 2700
QQQLEAEAQK HCEALRREKE RELELQRQRD LHKIKQLQQT VRDLESKDEV PGSRLHLGSA 2760
RRAAGSDADH LREQQRELEA MRQRLLSAAR LLTSFTSQAV DRTVNDWTSS NEKAVMSLLH 2820
TLEELKSDLS RPTSSQKKMA AELQFQFVDV LLKDNVSLTK ALSTVTQEKL ELSRAVSKLE 2880
KLLKHHLQKG CSPSRSERSA WKPDETAPQS SLRRPDPGRL PPAASEEAHT SNVKMEKLYL 2940
HYLRAESFRK ALIYQKKYLL LLIGGFQDSE QETLSMIAHL GVFPSKAERK ITSRPFTRFR 3000
TAVRVVIAIL RLRFLVKKWQ EVDRKGALAQ GKAPRPGPRA RQPQSPPRTR ESPPTRDVPS 3060
GHTRDPARGR RLAAAASPHS GGRATPSPNS RLERSLTASQ DPEHSLTEYI HHLEVIQQRL 3120
GGVLPDSTSK KSCHPMIKQ 3139 
Gene Ontology
 GO:0005814; C:centriole; IEA:Compara.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0045171; C:intercellular bridge; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0048854; P:brain morphogenesis; IEA:Compara.
 GO:0021696; P:cerebellar cortex morphogenesis; IEA:Compara.
 GO:0042384; P:cilium assembly; IDA:MGI.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0035108; P:limb morphogenesis; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IMP:UniProtKB.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0061351; P:neural precursor cell proliferation; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0021772; P:olfactory bulb development; IEA:Compara.
 GO:0007051; P:spindle organization; IEA:Compara. 
Interpro
 IPR019528; PACT_domain.
 IPR024151; Pericentrin. 
Pfam
 PF10495; PACT_coil_coil 
SMART
  
PROSITE
  
PRINTS