UniProt Accession

 RU2A_MOUSE; P57784; Q3U7R8; Q8K2W4; Q91YW1; Q9JKQ3 

Genbank Protein ID

 AF230356; BC013777; BC029642; AK088438; AK151800; AK152546; AK153502 

Genbank Nucleotide ID

 AAF35392.1; AAH13777.1; AAH29642.1; BAC40353.1; BAE30700.1; BAE31301.1; BAE32048.1 

Protein Name

 U2 small nuclear ribonucleoprotein A' 

Protein Synonyms/Alias

 U2 snRNP A' 

Gene Name

 Snrpa1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
172	KRGAQLAKDIARRSK	acetylation	[1, 2]
179	KDIARRSKTFNPGAG	acetylation	[1]
179	KDIARRSKTFNPGAG	ubiquitination	[3]
205	AGDVEAIKNAIANAS	ubiquitination	[3]
221	LAEVERLKGLLQSGQ	acetylation	[1]
221	LAEVERLKGLLQSGQ	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA (By similarity). 

Sequence Annotation

 REPEAT 20 41 LRR 1.
 REPEAT 43 64 LRR 2.
 REPEAT 65 86 LRR 3.
 REPEAT 89 110 LRR 4.
 DOMAIN 123 161 LRRCT.
 MOD_RES 172 172 N6-acetyllysine (By similarity).
 MOD_RES 178 178 Phosphoserine (By similarity).
 MOD_RES 197 197 Phosphoserine (By similarity).
 MOD_RES 239 239 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 255 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR003603; U2A'_phosphoprotein32A_C. 

Pfam

  

SMART

 SM00446; LRRcap 

PROSITE

 PS51450; LRR 

PRINTS