CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031274
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Activator of 90 kDa heat shock protein ATPase homolog 1 
Protein Synonyms/Alias
 cDNA FLJ56675, highly similar to Activator of 90 kDa heat shock protein ATPase homolog 1 
Gene Name
 AHSA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
3*****MAKWGEGDPRacetylation[1]
3*****MAKWGEGDPRubiquitination[1, 2]
94LNWTGTSKSGVQYKGubiquitination[3]
203QARPVGVKIPTCKITubiquitination[1, 2]
208GVKIPTCKITLKETFubiquitination[1, 2]
212PTCKITLKETFLTSPacetylation[1, 4]
212PTCKITLKETFLTSPubiquitination[2, 3]
249LEADRGGKFHMVDGNacetylation[1, 4]
249LEADRGGKFHMVDGNubiquitination[3]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 288 AA 
Protein Sequence
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ NEEGKCEVTE 60
VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK GHVEIPNLSD ENSVDEVEIS 120
VSLAKDEPDT NLVALMKEEG VKLLREAMGI YISTLKTEFT QGMILPTMNG ESVDPVGQPA 180
LKTEERKAKP APSKTQARPV GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA 240
TLEADRGGKF HMVDGNVSGE FTDLVPEKHI VMKWRFKSWP EGSHCHSG 288 
Gene Ontology
 GO:0001671; F:ATPase activator activity; IEA:InterPro.
 GO:0032781; P:positive regulation of ATPase activity; IEA:GOC.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR013538; Activator_of_Hsp90_ATPase.
 IPR015310; AHSA1_N.
 IPR023393; START-like_dom. 
Pfam
 PF09229; Aha1_N
 PF08327; AHSA1 
SMART
 SM01000; Aha1_N 
PROSITE
  
PRINTS