CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021135
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 2 
Protein Synonyms/Alias
 ATP-binding cassette transporter 2; ATP-binding cassette 2 
Gene Name
 Abca2 
Gene Synonyms/Alias
 Abc2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1336ENSEADVKESRKDALubiquitination[1]
1340ADVKESRKDALPGAEubiquitination[1]
2026QRLPVSTKPVEDDVDubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. 
Sequence Annotation
 DOMAIN 990 1221 ABC transporter 1.
 DOMAIN 2051 2286 ABC transporter 2.
 NP_BIND 1024 1031 ATP 1 (By similarity).
 NP_BIND 2088 2095 ATP 2 (By similarity).
 MOD_RES 1327 1327 Phosphoserine (By similarity).
 MOD_RES 1331 1331 Phosphoserine (By similarity).
 MOD_RES 2411 2411 Phosphothreonine (By similarity).
 CARBOHYD 14 14 N-linked (GlcNAc...) (Potential).
 CARBOHYD 89 89 N-linked (GlcNAc...) (Potential).
 CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 305 305 N-linked (GlcNAc...) (Potential).
 CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 379 379 N-linked (GlcNAc...) (Potential).
 CARBOHYD 420 420 N-linked (GlcNAc...) (Potential).
 CARBOHYD 432 432 N-linked (GlcNAc...) (Potential).
 CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
 CARBOHYD 484 484 N-linked (GlcNAc...) (Potential).
 CARBOHYD 494 494 N-linked (GlcNAc...) (Potential).
 CARBOHYD 530 530 N-linked (GlcNAc...) (Potential).
 CARBOHYD 549 549 N-linked (GlcNAc...) (Potential).
 CARBOHYD 590 590 N-linked (GlcNAc...) (Potential).
 CARBOHYD 600 600 N-linked (GlcNAc...) (Potential).
 CARBOHYD 628 628 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1247 1247 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1496 1496 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1549 1549 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1557 1557 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1613 1613 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1678 1678 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1776 1776 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2055 2055 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Endosome; Glycoprotein; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2434 AA 
Protein Sequence
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS VKEAFYTAAP 60
LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLN RVVEESNLFD PERPSLGSEL 120
EALHQRLEAL SSGPGTWESH SARPAVSSFS LDSVARDKRE LWRFLMQNLS LPNSTAQALL 180
AARVDPSEVY RLLFGPLPDL DGKLGFLRKQ EPWSHLGSNP LFQMEELLLA PALLEQLTCA 240
PGSGELGRIL TMPEGHQVDL QGYRDAVCSG QATARAQHFS DLATELRNQL DIAKIAQQLG 300
FNVPNGSDPQ PQAPSPQSLQ ALLGDLLDVQ KVLQDVDVLS ALALLLPQGA CAGRAPAPQA 360
GSPSGPANST GVGANTGPNT TVEEGTQSPV TPASPDTLQG QCSAFVQLWA GLQPILCGNN 420
RTIEPEALRR GNMSSLGFTS KEQRNLGLLV HLMTSNPKIL YAPAGSEADH VILKANETFA 480
FVGNVTHYAQ VWLNISAEIR SFLEQGRLQQ HLHWLQQYVA DLRLHPEAMN LSLDELPPAL 540
RLDYFSLPNG TALLQQLDTI DNAACGWIQF MSKVSVDIFK GFPDEESIVN YTLNQAYQDN 600
VTVFASVIFQ TRKDGSLPPH VHYKIRQNSS FTEKTNEIRR AYWRPGPNTG GRFYFLYGFV 660
WIQDMIERAI INTFVGHDVV EPGNYVQMFP YPCYTRDDFL FVIEHMMPLC MVISWVYSVA 720
MTIQHIVAEK EHRLKEVMKT MGLNNAVHWV AWFITGFVQL SISVTALTAI LKYGQVLMHS 780
HVLIIWLFLA VYAVATIMFC FLVSVLYSKA KLASACGGII YFLSYVPYMY VAIREEVAHD 840
KITAFEKCIA SLMSTTAFGL GSKYFALYEV AGVGIQWHTF SQSPVEGDDF NLLLAVTMLM 900
VDTVVYGVLT WYIEAVHPGM YGLPRPWYFP LQKSYWLGSG RTETWEWSWP WAHAPRLSVM 960
EEDQACAMES RHFEETRGME EEPTHLPLVV CVDKLTKVYK NDKKLALNKL SLNLYENQVV 1020
SFLGHNGAGK TTTMSILTGL FPPTSGSATI YGHDIRTEMD EIRKNLGMCP QHNVLFDQLT 1080
VEEHLWFYSR LKSMAQEEIR KEMDKMIEDL ELSNKRHSLV QTLSGGMKRK LSVAIAFVGG 1140
SRAIILDEPT AGVDPYARRA IWDLILKYKP GRTILLSTHH MDEADLLGDR IAIISHGKLK 1200
CCGSPLFLKG AYGDGYRLTL VKRPAEPGTS QEPGMASSPS GRPQLSNCSE MQVSQFIRKH 1260
VASSLLVSDT STELSYILPS EAVKKGAFER LFQQLEHSLD ALHLSSFGLM DTTLEEVFLK 1320
VSEEDQSLEN SEADVKESRK DALPGAEGLT AVESQAGNLA RCSELAQSQA SLQSASSVGS 1380
ARGDEGAGYT DGYGDYRPLF DNLQDPDSVS LQEAEMEALA RVGQGSRKLE GWWLKMRQFH 1440
GLLVKRFHCA RRNSKALCSQ ILLPAFFVCV AMTVALSVPE IGDLPPLVLS PSQYHNYTQP 1500
RGNFIPYANE ERREYRLRLS PDASPQQLVS TFRLPSGVGA TCVLKSPANG SLGPMLNLSS 1560
GESRLLAARF FDSMCLESFT QGLPLSNFVP PPPSPAPSDS PLSPDEDSLL AWNTSLPPTA 1620
GPETWTWAPS LPRLVHEPVR CTCSAQGTGF SCPSSVGGHP PQMRVVTGDI LTDITGHNVS 1680
EYLLFTSDRF RLHRYGAITF GNIQKSIPAP IGTRTPLMVR KIAVRRVAQV LYNNKGYHSM 1740
PTYLNSLNNA ILRANLPKSK GNPAAYGITV TNHPMNKTSA SLSLDYLLQG TDVVIAIFII 1800
VAMSFVPASF VVFLVAEKST KAKHLQFVSG CNPVIYWLAN YVWDMLNYLV PATCCIIILF 1860
VFDLPAYTSP TNFPAVLSLF LLYGWSITPI MYPASFWFEV PSSAYVFLIV INLFIGITAT 1920
VATFLLQLFE HDKDLKVVNS YLKSCFLIFP NYNLGHGLME IAYNEYINEY YAKIGQFDKM 1980
KSPFEWDIVT RGLVAMTVEG FVGFFLTIMC QYNFLRQPQR LPVSTKPVED DVDVASERQR 2040
VLRGDADNDM VKIENLTKVY KSRKIGRILA VDRLCLGVRP GECFGLLGVN GAGKTSTFKM 2100
LTGDESTTGG EAFVNGHSVL KDLLQVQQSL GYCPQFDALF DELTAREHLQ LYTRLRGIPW 2160
KDEAQVVRWA LEKLELTKCA DKPAGSYSGG NKRKLSTAIA LIGYPAFIFL DEPTTGMDPK 2220
ARRFLWNLIL DLIKTGRSVV LTSHSMEECE AVCTRLAIMV NGRLRCLGSI QHLKNRFGDG 2280
YMITVRTKSS QNVKDVVRFF NRNFPEAMLK ERHHTKVQYQ LKSEHISLAQ VFSKMEHVVG 2340
VLGIEDYSVS QTTLDNVFVN FAKKQSDNVE QQEAEPSTLP SPLGLLSLLR PRPAPTELRA 2400
LVADEPEDLD TEDEGLISFE EERAQLSFNT DTLC 2434 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:UniProtKB.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISS:UniProtKB.
 GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
 GO:0005815; C:microtubule organizing center; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0016887; F:ATPase activity; ISS:UniProtKB.
 GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
 GO:0032383; P:regulation of intracellular cholesterol transport; ISS:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0048545; P:response to steroid hormone stimulus; ISS:UniProtKB.
 GO:0006810; P:transport; NAS:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS