CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009533
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin, aortic smooth muscle 
Protein Synonyms/Alias
 Alpha-actin-2 
Gene Name
 Acta2 
Gene Synonyms/Alias
 Actsa; Actvs 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
70KRGILTLKYPIEHGIacetylation[1]
86TNWDDMEKIWHHSFYacetylation[1]
115TEAPLNPKANREKMTacetylation[1]
293KCDIDIRKDLYANNVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 
Sequence Annotation
 MOD_RES 3 3 N-acetylglutamate (By similarity).
 MOD_RES 46 46 Methionine sulfoxide (By similarity).
 MOD_RES 75 75 Tele-methylhistidine (By similarity).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Methylation; Muscle protein; Nucleotide-binding; Oxidation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA 60
QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK 120
MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL 180
DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK 240
SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV 300
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS 360
KQEYDEAGPS IVHRKCF 377 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006936; P:muscle contraction; IDA:RGD. 
Interpro
 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 
PRINTS
 PR00190; ACTIN.