CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011307
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caldesmon 
Protein Synonyms/Alias
 CDM 
Gene Name
 CALD1 
Gene Synonyms/Alias
 CAD; CDM 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
640PFKCFTPKGSSLKIEacetylation[1]
645TPKGSSLKIEERAEFacetylation[1]
655ERAEFLNKSVQKSSGubiquitination[2]
718NIKSMWEKGNVFSSPubiquitination[2]
733TAAGTPNKETAGLKVubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). 
Sequence Annotation
 REPEAT 319 332 1.
 REPEAT 333 346 2.
 REPEAT 347 360 3.
 REGION 26 207 Myosin and calmodulin-binding (By
 REGION 319 375 3 X 14 AA tandem repeats of E-E-E-K-R-A-
 REGION 564 621 Tropomyosin-binding (Potential).
 REGION 653 686 Strong actin-binding (By similarity).
 REGION 664 674 Tropomyosin-binding (Potential).
 REGION 716 722 Calmodulin-binding (By similarity).
 REGION 768 793 Weak actin-binding (By similarity).
 MOD_RES 73 73 Phosphoserine.
 MOD_RES 643 643 Phosphoserine.
 MOD_RES 724 724 Phosphoserine.
 MOD_RES 730 730 Phosphothreonine.
 MOD_RES 753 753 Phosphothreonine.
 MOD_RES 759 759 Phosphoserine (By similarity).
 MOD_RES 789 789 Phosphoserine.  
Keyword
 Actin-binding; Alternative splicing; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Muscle protein; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 793 AA 
Protein Sequence
MDDFERRREL RRQKREEMRL EAERIAYQRN DDDEEEAARE RRRRARQERL RQKQEEESLG 60
QVTDQVEVNA QNSVPDEEAK TTTTNTQVEG DDEAAFLERL ARREERRQKR LQEALERQKE 120
FDPTITDASL SLPSRRMQND TAENETTEKE EKSESRQERY EIEETETVTK SYQKNDWRDA 180
EENKKEDKEK EEEEEEKPKR GSIGENQVEV MVEEKTTESQ EETVVMSLKN GQISSEEPKQ 240
EEEREQGSDE ISHHEKMEEE DKERAEAERA RLEAEERERI KAEQDKKIAD ERARIEAEEK 300
AAAQERERRE AEERERMREE EKRAAEERQR IKEEEKRAAE ERQRIKEEEK RAAEERQRIK 360
EEEKRAAEER QRARAEEEEK AKVEEQKRNK QLEEKKHAMQ ETKIKGEKVE QKIEGKWVNE 420
KKAQEDKLQT AVLKKQGEEK GTKVQAKREK LQEDKPTFKK EEIKDEKIKK DKEPKEEVKS 480
FMDRKKGFTE VKSQNGEFMT HKLKHTENTF SRPGGRASVD TKEAEGAPQV EAGKRLEELR 540
RRRGETESEE FEKLKQKQQE AALELEELKK KREERRKVLE EEEQRRKQEE ADRKLREEEE 600
KRRLKEEIER RRAEAAEKRQ KMPEDGLSDD KKPFKCFTPK GSSLKIEERA EFLNKSVQKS 660
SGVKSTHQAA IVSKIDSRLE QYTSAIEGTK SAKPTKPAAS DLPVPAEGVR NIKSMWEKGN 720
VFSSPTAAGT PNKETAGLKV GVSSRINEWL TKTPDGNKSP APKPSDLRPG DVSSKRNLWE 780
KQSVDKVTSP TKV 793 
Gene Ontology
 GO:0030478; C:actin cap; IEA:Compara.
 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003779; F:actin binding; TAS:ProtInc.
 GO:0005516; F:calmodulin binding; TAS:ProtInc.
 GO:0005523; F:tropomyosin binding; TAS:ProtInc.
 GO:0006928; P:cellular component movement; TAS:UniProtKB.
 GO:0006936; P:muscle contraction; TAS:Reactome. 
Interpro
 IPR006017; Caldesmon.
 IPR006018; Caldesmon_LSP. 
Pfam
 PF02029; Caldesmon 
SMART
  
PROSITE
  
PRINTS
 PR01076; CALDESMON.