| Tag | Content |
|---|
| CPLM ID | CPLM-026033 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carbamoyl-phosphate synthase large chain |
Protein Synonyms/Alias | Carbamoyl-phosphate synthetase ammonia chain |
Gene Name | carB |
Gene Synonyms/Alias | GK0795 |
Created Date | July 27, 2013 |
Organism | Geobacillus kaustophilus (strain HTA426) |
NCBI Taxa ID | 235909 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 984 | LAVIDLGKEEGEANK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus. Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG. Proteomics. 2013 Aug;13(15):2278-82. [ PMID: 23696451] |
Functional Description | |
Sequence Annotation | DOMAIN 133 327 ATP-grasp 1 (By similarity).
DOMAIN 675 862 ATP-grasp 2 (By similarity).
NP_BIND 159 216 ATP (By similarity).
NP_BIND 701 755 ATP (By similarity).
REGION 1 401 Carboxyphosphate synthetic domain (By
REGION 402 548 Oligomerization domain (By similarity).
REGION 549 931 Carbamoyl phosphate synthetic domain (By
REGION 932 1042 Allosteric domain (By similarity).
METAL 284 284 Magnesium or manganese 1 (By similarity).
METAL 298 298 Magnesium or manganese 1 (By similarity).
METAL 298 298 Magnesium or manganese 2 (By similarity).
METAL 300 300 Magnesium or manganese 2 (By similarity).
METAL 821 821 Magnesium or manganese 3 (By similarity).
METAL 833 833 Magnesium or manganese 3 (By similarity).
METAL 833 833 Magnesium or manganese 4 (By similarity).
METAL 835 835 Magnesium or manganese 4 (By similarity). |
Keyword | Amino-acid biosynthesis; Arginine biosynthesis; ATP-binding; Complete proteome; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Pyrimidine biosynthesis; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1042 AA |
Protein Sequence | MPKDSSLQSI LLIGSGPIVI GQAAEFDYSG TQACIALKEE GYRVILVNNN PATIMTDDVH 60
ADAVYFEPLT VEAVEAIIAK ERPDGLLATF GGQTGLNLAF QLHEAGVLEK YGVRLLGTPI 120
EAIKRGEDRE AFRALMHELG EPVPESEIVT SVEEAVAFAE QIGFPIIIRP AYTLGGTGGG 180
IAENMEQFLA LVEKGLNESP IHQCLIERSV AGFKEIEYEV MRDQSNTCIT VCNMENVDPV 240
GIHTGDSIVV APSQTLTDEE YQMLRSSAVK IISALGIIGG CNIQFALDPN SKQYYLIEVN 300
PRVSRSSALA SKATGYPIAR IAAKLAVGYT LAELVNPVTK TTYASFEPAL DYVVVKFPRL 360
PFDKFPHADR KLGTQMKATG EVMAIDRNME RAFQKAVQSL EGKNNGLLLP ELSAKTDDEL 420
KQLLVDKDDR RFFAMLELLR RGVSVEAIHK WTKIDRFFLC SFERLVALEK QAAAATLDTI 480
EEQTFRFLKE KGCSDAFLAE TWGVTELDVR NKRKELGIVP SYKMVDTCAA EFHSETDYYY 540
STYFGEDERK QPSGKEKVLI IGAGPIRIGQ GIEFDYSSVH SVFALQKEGY ETVMINNNPE 600
TVSTDFAVAD RLYFEPLTLE SVLDVIEAEQ IKHVIVQFGG QTAINLVKGL EEAGVPLLGV 660
TYDMIDQLED RDRFYQLLEE LDIPHVPGLV ANNAEELAAK AAEIGCPVLL RPSYVIGGRG 720
MFIVHSEAQL AALIEQGELT YPILIDAYLD GKEAEADIVT DGTDIVLPVI IEHVEKAGIH 780
SGDSYAWLPA QTLTGEEKAK IIDYAGRIAK KLGFKGIMNI QYVIADGNVY VLEVNPRASR 840
TVPIVSKTTG VPLAQIATKL LLGKSLVDIV DEKARGLAVM PYAVLKYPVF STHKLPGVDP 900
VVGPEMKSTG EGISIAATKE EAAYKAFYPY LQKKANANEV YVIGNIDAEL EAEMTAKQLT 960
IVADVPFADW VKRDTALAVI DLGKEEGEAN KRMTALSRQL LVFTERETLK LFLQALDVDH 1020
LDVQPIHGWL EKKKQAEQAV IA 1042 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:HAMAP. GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:HAMAP. GO:0000287; F:magnesium ion binding; IEA:HAMAP. GO:0030145; F:manganese ion binding; IEA:HAMAP. GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006526; P:arginine biosynthetic process; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |