CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 AF4/FMR2 family member 1 
Protein Synonyms/Alias
  
Gene Name
 AFF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
159QLDNWLTKVSQPAAPubiquitination[1]
319SSLPAPSKALSGPEPacetylation[2, 3]
469NKKIRLEKEIKSQSSacetylation[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 849 AA 
Protein Sequence
MTHSWPPPLT AIHTPSTAEP SKFPFPTKDS QHVSSVTQNQ KQYDTSSKTH SNSQQGTSSM 60
LEDDLQLSDS EDSDSEQTPE KPPSSSAPPS APQSLPEPVA SAHSSSAESE STSDSDSSSD 120
SESESSSSDS EENEPLETPA PEPEPPTTNK WQLDNWLTKV SQPAAPPEGP RSTEPPRRHP 180
ESKGSSDSAT SQEHSESKDP PPKSSSKAPR APPEAPHPGK RSCQKSPAQQ EPPQRQTVGT 240
KQPKKPVKAS ARAGSRTSLQ GEREPGLLPY GSRDQTSKDK PKVKTKGRPR AAASNEPKPA 300
VPPSSEKKKH KSSLPAPSKA LSGPEPAKDN VEDRTPEHFA LVPLTESQGP PHSGSGSRTS 360
GCRQAVVVQE DSRKDRLPLP LRDTKLLSPL RDTPPPQSLM VKITLDLLSR IPQPPGKGSR 420
QRKAEDKQPP AGKKHSSEKR SSDSSSKLAK KRKGEAERDC DNKKIRLEKE IKSQSSSSSS 480
SHKESSKTKP SRPSSQSSKK EMLPPPPVSS SSQKPAKPAL KRSRREADTC GQDPPKSASS 540
TKSNHKDSSI PKQRRVEGKG SRSSSEHKGS SGDTANPFPV PSLPNGNSKP GKPQVKFDKQ 600
QADLHMREAK KMKQKAELMT DRVGKAFKYL EAVLSFIECG IATESESQSS KSAYSVYSET 660
VDLIKFIMSL KSFSDATAPT QEKIFAVLCM RCQSILNMAM FRCKKDIAIK YSRTLNKHFE 720
SSSKVAQAPS PCIARSTGTP SPLSPMPSPA SSVGSQSSAG SVGSSGVAAT ISTPVTIQNM 780
TSSYVTITSH VLTAFDLWEQ AEALTRKNKE FFARLSTNVC TLALNSSLVD LVHYTRQGFQ 840
QLQELTKTP 849 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara. 
Interpro
 IPR007797; TF_AF4/FMR2. 
Pfam
 PF05110; AF-4 
SMART
  
PROSITE
  
PRINTS