CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043094
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase MRCK beta 
Protein Synonyms/Alias
  
Gene Name
 CDC42BPB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138RTLDPLWKVRRSQKLubiquitination[1]
436SLLGAPSKTSSLLILubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 667 AA 
Protein Sequence
XALQKEILML KDKLEKSKRE RHNEMEEAVG TIKDKYERER AMLFDENKKL TAENEKLCSF 60
VDKLTAQNRQ LEDELQDLAA KKESVAHWEA QIAEIIQWVS DEKDARGYLQ ALASKMTEEL 120
EALRSSSLGS RTLDPLWKVR RSQKLDMSAR LELQSALEAE IRAKQLVQEE LRKVKDANLT 180
LESKLKDSEA KNRELLEEME ILKKKMEEKF RADTGLKLPD FQDSIFEYFN TAPLAHDLTF 240
RTSSASEQET QAPKPEASPS MSVAASEQQE PKAHQFSIKS FSSPTQCSHC TSLMVGLIRQ 300
GYACEVCSFA CHVSCKDGAP QVCPIPPEQS KRPLGVDVQR GIGTAYKGHV KVPKPTGVKK 360
GWQRAYAVVC DCKLFLYDLP EGKSTQPGVI ASQVLDLRDD EFSVSSVLAS DVIHATRRDI 420
PCIFRVTASL LGAPSKTSSL LILTENENEK RKWVGILEGL QSILHKNRLR NQVVHVPLEA 480
YDSSLPLIKA ILTAAIVDAD RIAVGLEEGL YVIEVTRDVI VRAADCKKVH QIELAPREKI 540
VILLCGRNHH VHLYPWSSLD GAEGSFDIKL PETKGCQLMA TATLKRNSGT CLFVAVKRLI 600
LCYEIQRTKP FHRKFNEIVA PGSVQCLAVL RDRLCVGYPS GFCLLSIQGD GQPLNLVNPN 660
DPSLAFL 667 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
 GO:0031532; P:actin cytoskeleton reorganization; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001180; Citron.
 IPR020454; DAG/PE-bd.
 IPR014930; Myotonic_dystrophy_kinase_coil.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR026611; Ser/Thr_kinase_MRCK. 
Pfam
 PF00130; C1_1
 PF00780; CNH
 PF08826; DMPK_coil 
SMART
 SM00109; C1
 SM00233; PH 
PROSITE
 PS50219; CNH
 PS50003; PH_DOMAIN
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00008; DAGPEDOMAIN.