CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006749
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-succinylbenzoate--CoA ligase 
Protein Synonyms/Alias
 o-succinylbenzoyl-CoA synthetase; OSB-CoA synthetase 
Gene Name
 menE 
Gene Synonyms/Alias
 b2260; JW2255 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
241NRSSVSLKAVLLGGAacetylation[1]
299PLPGREVKIVNNEVWacetylation[2]
Reference
 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA). 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Ligase; Menaquinone biosynthesis; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 451 AA 
Protein Sequence
MIFSDWPWRH WRQVRGETIA LRLNDEQLNW RELCARVDEL ASGFAVQGVV EGSGVMLRAW 60
NTPQTLLAWL ALLQCGARVL PVNPQLPQPL LEELLPNLTL QFALVPDGEN TFPALTSLHI 120
QLVEGAHAAT WQPTRLCSMT LTSGSTGLPK AAVHTYQAHL ASAQGVLSLI PFGDHDDWLL 180
SLPLFHVSGQ GIMWRWLYAG ARMTVRDKQP LEQMLAGCTH ASLVPTQLWR LLVNRSSVSL 240
KAVLLGGAAI PVELTEQARE QGIRCFCGYG LTEFASTVCA KEADGLADVG SPLPGREVKI 300
VNNEVWLRAA SMAEGYWRNG QLVSLVNDEG WYATRDRGEM HNGKLTIVGR LDNLFFSGGE 360
GIQPEEVERV IAAHPAVLQV FIVPVADKEF GHRPVAVMEY DHESVDLSEW VKDKLARFQQ 420
PVRWLTLPPE LKNGGIKISR QALKEWVQRQ Q 451 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008756; F:o-succinylbenzoate-CoA ligase activity; IDA:EcoCyc.
 GO:0009234; P:menaquinone biosynthetic process; IMP:EcoCyc. 
Interpro
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR010192; MenE.
 IPR023015; SB_CoA_ligase_firmicutes. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS